Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-248]

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

AGENCY:

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

ACTION:

Request for comments on the proposed substances to be evaluated for Set 23 toxicological profiles.

SUMMARY:

This notice announces the list of proposed substances that will be evaluated for CERCLA Set 23 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public nominations from the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the evaluation of any additional substances that may have public health implications.

DATES:

Nominations must be submitted by December 24th, 2008.

ADDRESSES:

Nominations may be submitted electronically, by mail, or by facsimile. Refer to the section

Submission of Nominations

(below) for specific addresses and/or the facsimile number.

FOR FURTHER INFORMATION:

Contact Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (770) 488-3313.

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601

et seq.

] amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 U.S.C. 9601

et seq.

] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This list has identified 275 hazardous substances that ATSDR and EPA determined pose the most significant potential threat to human health. The availability of the revised list of the 275 priority substances was announced in the

Federal Register

on March 6, 2008 (73 FR 12178). For previous versions of the list of substances, see

Federal Register

notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 2005 (70 FR 70284).

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

Each year, ATSDR develops a list of priority substances that will be evaluated for toxicological profile development. This list was compiled, on the basis of ATSDR's Priority List of Hazardous Substances, with consideration of the amount of relevance of newly published scientific

literature. The following 80 substances will be evaluated:

Name

CAS

1

MERCURY

007439-97-6

METHYLMERCURY

022967-92-6

MERCURIC CHLORIDE

007487-94-7

2

POLYCHLORINATED BIPHENYLS

001336-36-3

AROCLOR 1254

011097-69-1

AROCLOR 1260

011096-82-5

AROCLOR 1248

012672-29-6

AROCLOR 1242

053469-21-9

AROCLOR

012767-79-2

AROCLOR 1221

011104-28-2

AROCLOR 1016

012674-11-2

AROCLOR 1232

011141-16-5

AROCLOR 1240

071328-89-7

TETRACHLOROBIPHENYL

026914-33-0

3

POLYCYCLIC AROMATIC HYDROCARBONS

130498-29-2

BENZO(A)PYRENE

000050-32-8

BENZO(B)FLUORANTHENE

000205-99-2

DIBENZO(A,H)ANTHRACENE

000053-70-3

BENZO(A)ANTHRACENE

000056-55-3

BENZO(K)FLUORANTHENE

000207-08-9

BENZOFLUORANTHENE

056832-73-6

FLUORANTHENE

000206-44-0

CHRYSENE

000218-01-9

ACENAPHTHENE

000083-32-9

INDENO(1,2,3-CD)PYRENE

000193-39-5

BENZOPYRENE

073467-76-2

PHENANTHRENE

000085-01-8

PYRENE

000129-00-0

FLUORENE

000086-73-7

ANTHRACENE

000120-12-7

BENZO(A)FLUORANTHENE

000203-33-8

BENZO(GHI)PERYLENE

000191-24-2

ACENAPHTHYLENE

000208-96-8

BENZO(J)FLUORANTHENE

000205-82-3

BENZO(E)PYRENE

000192-97-2

BENZOPERYLENE

011057-45-7

BENZO(B)ANTHRACENE

000092-24-0

DIBENZ(A,J)ANTHRACENE

000224-41-9

BENZO(GHI)FLUORANTHENE

000203-12-3

1-METHYLPYRENE

002381-21-7

4

CHLOROFORM

000067-66-3

5

DDT, P,P′-

000050-29-3

DDE, P,P′-

000072-55-9

DDD, P,P′-

000072-54-8

DDT, O,P′-

000789-02-6

DDD, O,P′

-000053-19-0

DDE, O,P′-

003424-82-6

6

TRICHLOROETHYLENE

000079-01-6

7

DIELDRIN

000060-57-1

ALDRIN

000309-00-2

8

CHLORDANE

000057-74-9

CIS-CHLORDANE

005103-71-9

TRANS-CHLORDANE

005103-74-2

OXYCHLORDANE

027304-13-8

GAMMA-CHLORDENE

056641-38-4

CHLORDANE, TECHNICAL

012789-03-6

ALPHA-CHLORDENE

056534-02-2

NONACHLOR, TRANS-

039765-80-5

NONACHLOR, CIS-

005103-73-1

CHLORDENE

003734-48-3

9

HEXACHLOROBUTADIENE

000087-68-3

10

COAL TAR CREOSOTE

008001-58-9

COAL TARS

008007-45-2

COAL TAR PITCH

065996-93-2

11

BENZIDINE

000092-87-5

12

TOXAPHENE

008001-35-2

13

TETRACHLOROETHYLENE

000127-18-4

14

1,2-DIBROMOETHANE

000106-93-4

15

DISULFOTON

000298-04-4

16

3,3′-DICHLOROBENZIDINE

000091-94-1

17

ENDRIN

000072-20-8

ENDRIN KETONE

053494-70-5

ENDRIN ALDEHYDE

007421-93-4

18

BERYLLIUM

007440-41-7

19

1,2-DIBROMO-3-CHLOROPROPANE

000096-12-8

DIBROMOCHLOROPROPANE

067708-83-2

20

PENTACHLOROPHENOL

000087-86-5

21

DI-N-BUTYL PHTHALATE

000084-74-2

22

ENDOSULFAN

000115-29-7

ENDOSULFAN SULFATE

001031-07-8

ENDOSULFAN, ALPHA

000959-98-8

ENDOSULFAN, BETA

033213-65-9

23

METHOXYCHLOR

000072-43-5

24

METHANE

000074-82-8

25

TOLUENE

000108-88-3

26

2-HEXANONE

000591-78-6

27

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

001746-01-6

HEXACHLORODIBENZO-P-DIOXIN

034465-46-8

HEPTACHLORODIBENZO-P-DIOXIN

037871-00-4

TETRACHLORODIBENZO-P-DIOXIN

041903-57-5

PENTACHLORODIBENZO-P-DIOXIN

036088-22-9

1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN

035822-46-9

OCTACHLORODIBENZO-P-DIOXIN

003268-87-9

1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN

057653-85-7

1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN

039227-28-6

1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN

019408-74-3

1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN

040321-76-4

28

DI(2-ETHYLHEXYL)PHTHALATE

000117-81-7

29

1,1-DICHLOROETHENE

000075-35-4

30

METHYLENE CHLORIDE

000075-09-2

31

BROMODICHLOROETHANE

000683-53-4

32

1,2-DICHLOROETHANE

000107-06-2

33

2,4,6-TRICHLOROPHENOL

000088-06-2

TETRACHLOROPHENOL

025167-83-3

2,4-DICHLOROPHENOL

000120-83-2

2,4,5-TRICHLOROPHENOL

000095-95-4

2-CHLOROPHENOL

000095-57-8

2,3,4,5-TETRACHLOROPHENOL

004901-51-3

2,3,5,6-TETRACHLOROPHENOL

000935-95-5

2,3,4,6-TETRACHLOROPHENOL

000058-90-2

4-CHLOROPHENOL

000106-48-9

CHLOROPHENOL

025167-80-0

34

2,4-DINITROPHENOL

000051-28-5

35

BIS(2-CHLOROETHYL) ETHER

000111-44-4

36

ASBESTOS

001332-21-4

CHRYSOTILE ASBESTOS

012001-29-5

AMOSITE ASBESTOS

012172-73-5

37

HEXACHLOROBENZENE

000118-74-1

38

2,4-DINITROTOLUENE

000121-14-2

DINITROTOLUENE

025321-14-6

2,6-DINITROTOLUENE

000606-20-2

39

RADIUM-226

013982-63-3

RADIUM

007440-14-4

RADIUM-228

015262-20-1

RADIUM-224

013233-32-4

40

ETHION

000563-12-2

41

THORIUM

007440-29-1

THORIUM-230

014269-63-7

THORIUM-228

014274-82-9

42

4,6-DINITRO-O-CRESOL

000534-52-1

42

CHLOROBENZENE

000108-90-7

44

N-NITROSODI-N-PROPYLAMINE

000621-64-7

45

1,2,3-TRICHLOROBENZENE

000087-61-6

46

POLONIUM-210

013981-52-7

47

CHLORPYRIFOS

002921-88-2

48

NEPTUNIUM-237

013994-20-2

49

CHLORDECONE

000143-50-0

MIREX

002385-85-5

50

S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE

000078-48-8

51

BROMINE

007726-95-6

52

DICOFOL

000115-32-2

53

PARATHION

000056-38-2

54

SELENIUM

007782-49-2

55

TRICHLOROFLUOROETHANE

027154-33-2

56

TRIFLURALIN

001582-09-8

57

4,4′-METHYLENEBIS(2-CHLOROANILINE)

000101-14-4

58

PENTACHLOROBENZENE

000608-93-5

59

1,3-BUTADIENE

000106-99-0

60

1,1-DICHLOROETHANE

000075-34-3

61

1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN

039001-02-0

HEPTACHLORODIBENZOFURAN

038998-75-3

2,3,4,7,8-PENTACHLORODIBENZOFURAN

057117-31-4

HEXACHLORODIBENZOFURAN

055684-94-1

PENTACHLORODIBENZOFURAN

030402-15-4

2,3,7,8-TETRACHLORODIBENZOFURAN

051207-31-9

DIBENZOFURANS, CHLORINATED

042934-53-2

1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN

067562-39-4

1,2,3,7,8,9-HEXACHLORODIBENZOFURAN

072918-21-9

TETRACHLORODIBENZOFURAN

030402-14-3

1,2,3,6,7,8-HEXACHLORODIBENZOFURAN

057117-44-9

1,2,3,4,7,8-HEXACHLORODIBENZOFURAN

070648-26-9

2,3,4,6,7,8-HEXACHLORODIBENZOFURAN

060851-34-5

1,2,3,7,8-PENTACHLORODIBENZOFURAN

057117-41-6

1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN

055673-89-7

62

1,1,2-TRICHLOROETHANE

000079-00-5

63

HEXACHLOROCYCLOPENTADIENE

000077-47-4

64

1,2-DIPHENYLHYDRAZINE

000122-66-7

65

1,2-DICHLOROETHENE, TRANS-

000156-60-5

1,2-DICHLOROETHYLENE

000540-59-0

1,2-DICHLOROETHENE, CIS-

000156-59-2

66

CARBON DISULFIDE

000075-15-0

67

PALLADIUM

007440-05-3

68

CHLOROETHANE

000075-00-3

98

ACETONE

000067-64-1

70

DIBENZOFURAN

000132-64-9

71

2,4-DIMETHYLPHENOL

000105-67-9

72

CARBON MONOXIDE

000630-08-0

73

CHLOROMETHANE

000074-87-3

74

BUTYL BENZYL PHTHALATE

000085-68-7

75

VANADIUM

007440-62-2

76

N-NITROSODIMETHYLAMINE

000062-75-9

77

1,2,4-TRICHLOROBENZENE

000120-82-1

78

N-NITROSODIPHENYLAMINE

000086-30-6

79

2-BUTANONE

000078-93-3

80

FLUORINE

007782-41-4

HYDROGEN FLUORIDE

007664-39-3

FLUORIDE ION

016984-48-8

Submission of Nominations for the Evaluation Set 23 Proposed Substances:

Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the full name, title, affiliation, e-mail address and telephone number of the nominator.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances that will be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the

Selection Criteria

announced in the

Federal Register

on May 7th, 1993 (87 FR 27288).

Please submit nominations by one of the following methods:

• E-mail

jxt1@cdc.gov

.

• Fax 770.488.4178.

• Mail CDR Jessilynn Taylor, 1600 Clifton Rd, NE., MS F32, Atlanta, GA 30333.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time permits.

Dated: November 26, 2008.

Ken Rose,

Director, Office of Policy, Planning, and Evaluation National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.

[FR Doc. E8-28551 Filed 12-1-08; 8:45 am]

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