Proposed Substances To Be Evaluated for Set 22 Toxicological Profiles

Federal RegisterOct 25, 2007

Ask Donna

What actually matters in this document.

Text

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-235]

Proposed Substances To Be Evaluated for Set 22 Toxicological Profiles

AGENCY:

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

ACTION:

Request for comments on the proposed substances to be evaluated for Set 22 toxicological profiles.

SUMMARY:

This notice announces the list of proposed substances that will be evaluated for CERCLA Set 22

toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public nominations from the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the evaluation of any additional substances that may have public health implications.

DATES:

Nominations must be submitted within 30 days of the publication of this notice. The 30-day period begins October 26th, 2007 and ends November 26th, 2007.

ADDRESSES:

Nominations may be submitted electronically, by mail, or by facsimile. Refer to the section

Submission of Nominations

(below) for specific addresses and/or the facsimile number.

FOR FURTHER INFORMATION CONTACT:

Contact Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (770) 488-3313.

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601

et seq.

] amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 U.S.C. 9601

et seq.

] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This list has identified 275 hazardous substances that ATSDR and EPA determined pose the most significant potential threat to human health. The availability of the revised list of the 275 priority substances was announced in the

Federal Register

on December 7, 2005 (70 FR 702840). For prior versions of the list of substances, see

Federal Register

notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014) and November 7, 2003 (68 FR 63098).

Proposed Substances To Be Evaluated for Set 22 Toxicological Profiles

Each year, ATSDR develops a list of priority substances that will be evaluated for toxicological profile development. This list was compiled, on the basis of ATSDR's Priority List of Hazardous Substances, with consideration of the amount of relevance of newly published scientific literature. The following 73 substances will be evaluated:

Substance name

CAS No.

PERFLUOROOCTANOIC ACID

(1)

PERFLUOROCYL SULFONATES

(1)

MERCURY

007439-97-6

METHYLMERCURY

022967-92-6

MERCURIC CHLORIDE

007487-94-7

POLYCHLORINATED BIPHENYLS

001336-36-3

AROCLOR 1254

011097-69-1

AROCLOR 1260

011096-82-5

AROCLOR 1248

012672-29-6

AROCLOR 1242

053469-21-9

AROCLOR

012767-79-2

AROCLOR 1221

011104-28-2

AROCLOR 1016

012674-11-2

AROCLOR 1232

011141-16-5

AROCLOR 1240

071328-89-7

TETRACHLOROBIPHENYL

026914-33-0

CADMIUM

007440-43-9

POLYCYCLIC AROMATIC HYDROCARBONS

130498-29-2

BENZO(A)PYRENE

000050-32-8

BENZO(B)FLUORANTHENE

000205-99-2

DIBENZO(A,H)ANTHRACENE

000053-70-3

BENZO(A)ANTHRACENE

000056-55-3

BENZO(K)FLUORANTHENE

000207-08-9

BENZOFLUORANTHENE

056832-73-6

FLUORANTHENE

000206-44-0

CHRYSENE

000218-01-9

ACENAPHTHENE

000083-32-9

INDENO(1,2,3-CD)PYRENE

000193-39-5

BENZOPYRENE

073467-76-2

PHENANTHRENE

000085-01-8

PYRENE

000129-00-0

FLUORENE

000086-73-7

ANTHRACENE

000120-12-7

BENZO(A)FLUORANTHENE

000203-33-8

BENZO(GHI)PERYLENE

000191-24-2

ACENAPHTHYLENE

000208-96-8

BENZO(J)FLUORANTHENE

000205-82-3

BENZO(E)PYRENE

000192-97-2

BENZOPERYLENE

011057-45-7

BENZO(B)ANTHRACENE

000092-24-0

DIBENZ(A,J)ANTHRACENE

000224-41-9

BENZO(GHI)FLUORANTHENE

000203-12-3

1-METHYLPYRENE

002381-21-7

CHLOROFORM

000067-66-3

DDT, P,P′-

000050-29-3

DDE, P,P′-

000072-55-9

DDD, P,P′-

000072-54-8

DDT, O,P′-

000789-02-6

DDD, O,P′-

000053-19-0

DDE, O,P′-

003424-82-6

TRICHLOROETHYLENE

000079-01-6

IELDRIN

000060-57-1

ALDRIN

000309-00-2

CHROMIUM, HEXAVALENT

018540-29-9

CHROMIUM(VI) OXIDE

001333-82-0

CHROMIUM

007440-47-3

CHROMIUM TRIOXIDE

007738-94-5

CHROMIUM, TRIVALENT

016065-83-1

CHLORDANE

000057-74-9

CIS-CHLORDANE

005103-71-9

TRANS-CHLORDANE

005103-74-2

OXYCHLORDANE

027304-13-8

GAMMA-CHLORDENE

056641-38-4

CHLORDANE, TECHNICAL

012789-03-6

ALPHA-CHLORDENE

056534-02-2

NONACHLOR, TRANS-

039765-80-5

NONACHLOR, CIS-

005103-73-1

CHLORDENE

003734-48-3

HEXACHLOROBUTADIENE

000087-68-3

COAL TAR CREOSOTE

008001-58-9

COAL TARS

008007-45-2

COAL TAR PITCH

065996-93-2

BENZIDINE

000092-87-5

TOXAPHENE

008001-35-2

TETRACHLOROETHYLENE

000127-18-4

1,2-DIBROMOETHANE

000106-93-4

DISULFOTON

000298-04-4

3,3′-DICHLOROBENZIDINE

000091-94-1

BERYLLIUM

007440-41-7

ENDRIN

000072-20-8

ENDRIN KETONE

053494-70-5

ENDRIN ALDEHYDE

007421-93-4

1,2-DIBROMO-3-CHLOROPROPANE

000096-12-8

DIBROMOCHLOROPROPANE

067708-83-2

PENTACHLOROPHENOL

000087-86-5

DI-N-BUTYL PHTHALATE

000084-74-2

ENDOSULFAN SULFATE

001031-07-8

ENDOSULFAN

000115-29-7

ENDOSULFAN, ALPHA

000959-98-8

ENDOSULFAN, BETA

033213-65-9

METHOXYCHLOR

000072-43-5

METHANE

000074-82-8

TOLUENE

000108-88-3

2-HEXANONE

000591-78-6

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

001746-01-6

HEXACHLORODIBENZO-P-DIOXIN

034465-46-8

HEPTACHLORODIBENZO-P-DIOXIN

037871-00-4

TETRACHLORODIBENZO-P-DIOXIN

041903-57-5

PENTACHLORODIBENZO-P-DIOXIN

036088-22-9

1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN

035822-46-9

OCTACHLORODIBENZO-P-DIOXIN

003268-87-9

1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN

057653-85-7

1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN

039227-28-6

1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN

019408-74-3

1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN

040321-76-4

DI(2-ETHYLHEXYL)PHTHALATE

000117-81-7

1,1-DICHLOROETHENE

000075-35-4

METHYLENE CHLORIDE

000075-09-2

2,4,6-TRINITROTOLUENE

000118-96-7

BROMODICHLOROETHANE

000683-53-4

1,2-DICHLOROETHANE

000107-06-2

2,4,6-TRICHLOROPHENOL

000088-06-2

TETRACHLOROPHENOL

025167-83-3

2,4-DICHLOROPHENOL

000120-83-2

2,4,5-TRICHLOROPHENOL

000095-95-4

2-CHLOROPHENOL

000095-57-8

2,3,4,5-TETRACHLOROPHENOL

004901-51-3

2,3,5,6-TETRACHLOROPHENOL

000935-95-5

2,3,4,6-TETRACHLOROPHENOL

000058-90-2

4-CHLOROPHENOL

000106-48-9

CHLOROPHENOL

025167-80-0

2,4-DINITROPHENOL

000051-28-5

BIS(2-CHLOROETHYL) ETHER

000111-44-4

ASBESTOS

001332-21-4

CHRYSOTILE ASBESTOS

012001-29-5

AMOSITE ASBESTOS

012172-73-5

HEXACHLOROBENZENE

000118-74-1

RADIUM-226

013982-63-3

RADIUM

007440-14-4

RADIUM-228

015262-20-1

RADIUM-224

013233-32-4

2,4-DINITROTOLUENE

000121-14-2

DINITROTOLUENE

025321-14-6

2,6-DINITROTOLUENE

000606-20-2

ETHION

000563-12-2

THORIUM

007440-29-1

THORIUM-230

014269-63-7

THORIUM-228

014274-82-9

4,6-DINITRO-O-CRESOL

000534-52-1

RADON

010043-92-2

RADON-222

014859-67-7

RADON-220

022481-48-7

CHLOROBENZENE

000108-90-7

N-NITROSODI-N-PROPYLAMINE

000621-64-7

MANGANESE

007439-96-5

MANGANESE DIOXIDE

001313-13-9

POLONIUM-210

013981-52-7

LEAD-210

014255-04-0

CHLORPYRIFOS

002921-88-2

NEPTUNIUM-237

013994-20-2

CHLORDECONE

000143-50-0

MIREX

002385-85-5

S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE

000078-48-8

BROMINE

007726-95-6

1,2,3-TRICHLOROBENZENE

000087-61-6

DICOFOL

000115-32-2

PARATHION

000056-38-2

TRICHLOROFLUOROETHANE

027154-33-2

TRIFLURALIN

001582-09-8

4,4′-METHYLENEBIS(2-CHLOROANILINE)

000101-14-4

PENTACHLOROBENZENE

000608-93-5

1,1-DICHLOROETHANE

000075-34-3

1,1,2-TRICHLOROETHANE

000079-00-5

1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN

039001-02-0

HEPTACHLORODIBENZOFURAN

038998-75-3

2,3,4,7,8-PENTACHLORODIBENZOFURAN

057117-31-4

HEXACHLORODIBENZOFURAN

055684-94-1

PENTACHLORODIBENZOFURAN

030402-15-4

2,3,7,8-TETRACHLORODIBENZOFURAN

051207-31-9

DIBENZOFURANS, CHLORINATED

042934-53-2

1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN

067562-39-4

1,2,3,7,8,9-HEXACHLORODIBENZOFURAN

072918-21-9

TETRACHLORODIBENZOFURAN

030402-14-3

1,2,3,6,7,8-HEXACHLORODIBENZOFURAN

057117-44-9

1,2,3,4,7,8-HEXACHLORODIBENZOFURAN

070648-26-9

2,3,4,6,7,8-HEXACHLORODIBENZOFURAN

060851-34-5

1,2,3,7,8-PENTACHLORODIBENZOFURAN

057117-41-6

1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN

055673-89-7

TRICHLOROETHANE

025323-89-1

HEXACHLOROCYCLOPENTADIENE

000077-47-4

1,2-DIPHENYLHYDRAZINE

000122-66-7

NANOMATERIALS

VANADIUM

007440-62-2

FORMALDEHYDE

000050-00-0

(1)

Various.

Submission of Nominations for the Evaluation Set 22

Proposed Substances:

Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the nominator, including full name, title, affiliation, email address, and telephone number.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances that will be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the

Selection Criteria

announced in the

Federal Register

on May 7th, 1993 (87 FR 27288).

Please submit nominations by one of the following methods:

•

E-mail: jxt1@cdc.gov

•

Fax:

770.488.4178.

•

Mail:

CDR Jessilynn Taylor, 1600 Clifton Rd, NE., MS F32, Atlanta, GA, 30333.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time permits.

Dated: October 19, 2007.

Ken Rose,

Director, Office of Policy, Planning and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.

[FR Doc. E7-21018 Filed 10-24-07; 8:45 am]

BILLING CODE 4163-70-P

This is a copy of a public record, reproduced as it was published. It is not legal advice, and it may not be the version a court would rely on. Check the official source before you cite it.