National Toxicology Program; National Toxicology Program (NTP), Board of Scientific Counselors' Meeting; Review of Draft NTP Technical Reports

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Public Health Service

National Toxicology Program; National Toxicology Program (NTP),

Board of Scientific Counselors' Meeting; Review of Draft NTP Technical

Reports

Pursuant to Public Law 92-463, notice is hereby given of the next

meeting of the NTP Board of Scientific Counselors' Technical Reports

Review Subcommittee on December 9 and 10, 1997, in the Conference

Center, Building 101, South Campus, National Institute of Environmental

Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park,

North Carolina. The meeting will begin at 1:30 p.m. on December 9, and

at 8:30 a.m. on December 10, and is open to the public. The agenda

topic is the peer review of draft Technical Reports of long-term

toxicology and carcinogenesis studies from the National Toxicology

Program. Additionally, there will be a presentation made concerning

data obtained from transgenic mouse models on several of the chemicals

being reviewed.

Tentatively scheduled to be peer reviewed on December 9-10 are

draft Technical Reports of 10 two-year studies, listed alphabetically,

along with supporting information in the attached table. All studies

were done using Fischer 344 rats and B6C3F1 mice. The order

of review is given in the far right column of the table. Copies of the

draft Reports may be obtained, as available, from: Central Data

Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709

(919/541-3419), FAX (919/541-3687), email: [email protected]

Public comment on any of the Technical Reports is welcome. Persons

wanting to make a formal presentation regarding a particular Technical

Report must notify the Executive Secretary by telephone, by FAX, by

mail, or by email no later than December 4, 1997, and provide a written

copy in advance of the meeting so copies can be made and distributed to

all Subcommittee members, ad hoc expert consultants, and staff, and

made available at the meeting for attendees. Written statements should

supplement and may expand on the oral presentation. Oral presentations

should be limited to no more than five minutes.

The program would welcome receiving toxicology and carcinogenesis

information from completed, ongoing, or planned studies by others, as

well as current production data, human exposure information, and use

patterns for any of the chemicals listed in this announcement. Please

contact Central Data Management at the address given above, and they

will relay the information to the appropriate staff scientist.

The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233,

Research Triangle Park, North Carolina 27709 (telephone 919/541-3971;

FAX 919/541-0295; email [email protected]) will furnish agenda and a

roster of Subcommittee members and expert consultants prior to the

meeting. Summary minutes subsequent to the meeting will be available

upon request to Central Data Management.

Attachment.

Charles E. Leasure, Jr.,

Acting Director, National Toxicology Program.

Summary Data for Technical Reports Tentatively Scheduled for Review at the Meeting of the NTP Board of

Scientific Counselor's Technical Reports Review Subcommittee

[December 9-10, 1997]

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Technical route/ Review

Chemical CAS No. report number Primary uses Exposure levels order

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1-Chloro-2-Propanol, Technical, TR-477 Chemical intermediate for Dosed-Water (deionized 10

127-00-4. propylene oxide & other water): Rats: 0, 150,

organic compounds. 325, or 650 ppm; Mice:

0, 250, 500, or 1000

ppm (50/sex/group).

Coconut Oil Acid, Diethanolamine TR-479 Foam stabilizer in Topical (95% ethanol): 2

Condensate, 68603-42-9. shampoos and dishwashing Rats: 0, 50, or 100 mg/

liquids; dyeing kg; Mice: 0, 100, or

assistant in textile 200 mg/kg (50 sex/

processing. species/group).

Diethanolamine, 111-42-2......... TR-478 Production of textile Topical (ethanol): Male 1

lubricants. Rubber Rats: 0, 16, 32, or 64

chemicals intermediate; mg/kg; Female Rats: 0,

emulsifier in 8, 16, or 32 mg/kg;

agricultural chemicals, Mice: 0, 40, 80, or 160

cosmetics, and mg/kg (50/sex/species/

pharmaceuticals; gas group).

conditioning agent.

[[Page 61521]]

Furfuryl Alcohol, 098-00-0....... TR-482 Solvent for ethers and Inhalation (air): Rats & 8

esters; in manufacture Mice: 0, 2, 8, or 32

of phenolic and furan ppm (50/sex/species/

resins. chemical group).

intermediate. wetting

agent; liquid

propellant; flavoring

agent, obtained from

processing corncobs,

coffee beans.

Isobutene, 115-11-7.............. TR-487 Production of Inhalation (air): Rats & 6

diisobutylene, trimers, Mice: 0, 500, 2000, or

butyl rubber, 8000 ppm 50/sex/species/

antioxidants for foods, group).

packaging, food

supplements & plastics,

isooctane, high-octane

aviation gasoline,

polyisobutene resins.

(NTP Executive Summary).

Isoprene 78-79-5................. TR-486 Monomer and comonomer for Inhalation (air): Rats: 7

elastomers, prepared 0, 220, 700, or 7000

from turpentine, ppm; 50/sex/group).

petroleum products

(Merck 1989).

Lauric Acid, Diethanolamine TR-480 Foam stabilizer for Topical (95% ethanol): 3

Condensate, 120-40-1. liquid household Rats: 0, 50, or 100 mg/

detergents and shampoos. kg; Mice: 0, 100, or

200 mg/kg (50/sex/

species/group.

Oleic Acid, Diethanolamine TR-481 Surfactant in wax Topical (95% ethanol): 4

Condensate, 93-83-4. emulsion; to increae Rats: 0, 50, or 100 mg/

shampoo viscosity. kg; 50/sex/group; Mice:

0, 15, or 30 mg/kg; 55/

sex/group.

Pentachlorophenol, Purified, 87- TR-483 Wood preservative, Dosed-Feed (NIH-07); 5

86-5. fungicide, soil fumigant Rats: 0, 200, 400, or

for termites, preharvest 600 ppm; 50/sex/group--

defoliant, seed 1000 ppm Stop Study (60/

treatment for beans, sex).

preservative for paint,

leather, textiles, inks,

antibacterial agent in

disinfectants & cleaners

(HSDB 1990).

Pyridine 110-86-1................ TR-470 Solvent, organic Dosed-Water (deionized 9

synthesis, flavoring water): Rats: 0, 100,

ingredient, manufacture 200, or 400 ppm; Male

of fungicides, Mice: 0, 250, 500, or

pharmaceuticals, 1000 ppm; Female Mice:

dyestuff, explosives, 125, 250 or 500 ppm;

mfr. of vitamins, sulfa Male Wistar Rats: 0,

drugs, intermediate in 100, 200, or 400 ppm

manufacture of diquat & (50/sex/group).

paraquat, waterproofing

textiles (HSDB 1990).

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[FR Doc. 97-30203 Filed 11-17-97; 8:45 am]

BILLING CODE 4140-01-P