National Institute of Environmental Health Sciences Division of Intramural Research; Proposed Data Collection Available for Public Comment and Recommendation

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health

National Institute of Environmental Health Sciences Division of

Intramural Research; Proposed Data Collection Available for Public

Comment and Recommendation

In compliance with the requirement of Section 3506(c)(2)(A) of the

Paperwork Reduction Act of 1995 for opportunity for public comment on

proposed data collection projects, the National Institute of

Environmental Health Sciences (NIEHS) will publish periodic summaries

of proposed projects. To request more information on the proposed

project or to obtain a copy of the data collection plans and

instruments, call the NIEHS Project Clearance Liaison, at (919) 541-

5047.

Comments are invited on: (a) Whether the proposed collection of

information is necessary for the proper performance of the functions of

the agency, including whether the information shall have practical

utility; (b) the accuracy of the agency's estimate of the burden of the

proposed collection of information; (c) ways to enhance the quality,

utility, and clarity of the information to be collected; and (d) ways

to minimize the burden of the collection of information on respondents,

including through the use of automated collection techniques or other

forms of information technology.

This notice regards a request for OMB processing for a proposed

study: The Johnston County ADHD Study: Environmental, Reproductive and

Familial Risk Factors for Attention Deficit/Hyperactivity Disorder in

accordance with 5 CFR 1320.13 of the OMB guidelines. We received

emergency OMB clearance in June 1997 for conducting a pilot study for

this study which is being conducted June 1997-November 1997. The OMB

clearance for the pilot study expires in November 1997. We are now

applying for clearance for the full study which we anticipate beginning

in January 1998.

New--Proposed Project: The Johnston County ADHD Study:

Environmental, Reproductive and Familial Risk Factors for Attention-

Deficit/Hyperactivity Disorder. For the proposed study we plan to

collect questionnaire data from 350 teachers and 2400 parents. Data

will be collected over two years. Teachers will use a brief symptom

checklist to screen all the children in their class; about 8,000

children will be screened in all. We will conduct telephone interviews

with the mothers or guardians of children identified as possible cases

and a 15% random sample of control children. If children meet DSM-IV

criteria for ADHD after both screens, they will be considered cases.

The primary hypotheses of the study are that preterm delivery and other

reproductive risk factors increase risk of ADHD and childhood lead

exposure (measured in shed baby teeth) increases risk of ADHD. In year

two of the study we will use cheek swabs to collect DNA from 1,200

mothers, 1,200 children, 1,200 siblings and 1,200 fathers to study

possible genetic or familial risk factors for ADHD. The data collected

in this study will allow us to describe the prevalence of Attention

Deficit/Hyperactivity Disorder in Johnston County, how prevalence

varies by demographic profile, and to identify environmental,

reproductive and familial risk factors for the disorder.

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Estimated Estimated Average # Average burden

Type respondent number of number of responses per hours per Total burden

respondents responses respondent response hours

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Teachers....................... 350 10,150 29 .18 1827

Mother/guardian................ 2400 13,200 5.5 .32 4224

Father......................... 1,200 1,000 1 .17 204

Study child.................... 1,200 1,000 1 .17 204

Sibling........................ 1,200 1,200 1 .17 204

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Total Burden: 6,663 hours.

Total Burden per Year: 3,331.5 hours.

REQUEST FOR COMMENTS: Written comments and/or suggestions from the

public and affected agencies should address one or more of the

following points: (1) Evaluate whether the proposed collection of

information is necessary for the proper performance of the function of

the agency, including whether the information will have practical

utility; (2) Evaluate the accuracy of the agency's estimate of the

burden of the proposed collection of information, including the

validity of the methodology and assumptions used; (3) Enhance the

quality, utility, and clarity of the information to be collected; and

(4) Minimize the burden of the collection of information on those who

are to respond, including the use of appropriate automated, electronic,

mechanical, or other technological collection techniques or other forms

of information technology.

FOR FURTHER INFORMATION CONTACT: To request more information on the

proposed project or to obtain a copy of the data collection plans and

instruments, contact: Dr. Andrew Rowland, Senior Staff Fellow, NIEHS,

DIR/EDMP/Epidemiology Branch, PO Box 12233, RTP, NC 27709, or call non-

toll free number (919) 541-7886.

COMMENTS DUE DATE: Comments regarding this information collection are

best assured of having their full effect if received on or before

November 21, 1997.

Dated: September 10, 1997.

Charles Leasure,

Associate Director for Management, NIEHS.

[FR Doc. 97-25150 Filed 9-19-97; 8:45 am]

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