Proposed Collection; Comment Request; Transmission and Linkage Analysis of Alcoholism in a Southwestern American Indian Tribe; Collection of EEG Phenotypes Associated With Alcoholism

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health

Proposed Collection; Comment Request; Transmission and Linkage

Analysis of Alcoholism in a Southwestern American Indian Tribe;

Collection of EEG Phenotypes Associated With Alcoholism

SUMMARY: In compliance with Section 3506(c)(2)(A) of the Paperwork

Reduction Act of 1995, which provides for an opportunity for public

comment on proposed data collection projects, the National Institute on

Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health

(NIH) will publish periodic summaries of proposed projects to be

submitted to the Office of Management and Budget (OMB) for review and

approval.

[[Page 35517]]

Proposed Collection

The Laboratory of Neurogenetics (LN), Division of Intramural

Clinical and Biological Research, NIAAA, intends to conduct the study

for `Transmission and Linkage Analysis of Alcoholism in a Southwestern

American Indian Tribe; Collection of EEG Phenotypes Associated with

Alcoholism.'

The LN is authorized by Section 452 of Part G of Title IV of the

Public Health Service Act (42 U.S.C. 288) as amended by the NIH

Revitalization Act of 1993 (Pub. Law 103-43). The information proposed

for collection in this study will be used by the NIAAA to determine

resting EEG and ERP phenotypes in large American Indian families,

correlate this information with psychiatric diagnoses from previous

studies, and perform linkage analysis in order to map the genes for

these phenotypes which to appear to confer vulnerability to alcoholism

in Caucasians. There are obvious great advantages in studying the large

families the NIAAA already contacted, psychiatrically interviewed, and

genotyped. The NIAAA hypothesizes that this EEG family study will

enable elucidation of the transmission and linkage of alcoholism

vulnerability in this tribe. The intent is to identify subgroups of

American Indian alcoholics who may be more responsive to particular

treatment of prevention strategies.

The annual burden estimates are as follows:

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Responses

Type and number of respondents per Total Hours Total hours

respondent responses

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Clients--400................................................ 1 400 2.25 900

Total Number of Respondents................................. ........... 400 ........... ...........

Total Number of Responses................................... ........... 400 ........... ...........

Total Hours................................................. ........... 900 ........... ...........

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Request for Comments

Comments are invited on: (a) whether the proposed collection is

necessary, including whether the information has practical use; (b)

ways to enhance the clarity, quality, and use of the information to be

collected; (c) the accuracy of the agency estimate of burden of the

proposed collection; and (d) ways to minimize the collection burden of

the respondents. Send written comments to Ms. Ronni Nelson, Laboratory

of Neurogenetics, Division of Intramural Clinical and Biological

Research, NIAAA, NIH, Park Bldg. Room 451, 12420 Parklawn Drive MSC

8110, Rockville, Maryland 20852.

FOR FURTHER INFORMATION: To request more information on the proposed

project or to obtain a copy of the data collection plans, contact Ms.

Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural

Clinical and Biological Research, NIAAA, Park Bldg. Room 451, 12420

Parklawn Drive MSC 8110, Rockville, Maryland 20852, or call non-toll-

free number (301) 443-5781.

COMMENTS DUE DATE: Comments regarding this information collection are

best assured of having their full effect if received on or before

September 2, 1997.

Dated: June 19, 1997.

Martin K. Trusty,

Executive Officer, NIAAA.

[FR Doc. 97-17200 Filed 6-30-97; 8:45 am]

BILLING CODE 4140-01-M