Proposed Collection; Comment Request; Mapping Alcoholism Related Genes by Linkage Disequilibrium in Choctaw American Indians With Mixed Ancestry

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health

Proposed Collection; Comment Request; Mapping Alcoholism Related

Genes by Linkage Disequilibrium in Choctaw American Indians With Mixed

Ancestry

SUMMARY: In compliance with Section 3506(c)(2)(A) of the Paperwork

Reduction Act of 1995, which provides for an opportunity for public

comment on proposed data collection projects, the National Institute on

Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health

(NIH) will publish periodic summaries of proposed projects to be

submitted to the Office of Management and Budget (OMB) for review and

approval.

Proposed Collection

The Laboratory of Neurogenetics (LN), Division of Intramural

Clinical and Biological Research, NIAAA, intends to conduct the study

for `Mapping Alcoholism Related Genes by Linkage Disequilibrium in

Choctaw American Indians with Mixed Ancestry'.

The LN is authorized by Section 452 of Part G of Title IV of the

Public Health Service Act (42 U.S.C. 288) as amended by the NIH

Revitalization Act of 1993 (Pub. Law 103-43). The information proposed

for collection in this study will be used by the NIAAA to expand the

Choctaw Indian study by sampling people and families that exhibit a

spectrum of Indian and non-Indian ancestry. This is possible because

the Choctaw have approximately 100,000 enrolled members and 95% of them

have some degree of non-Indian heritage. It is now recognized that

admixed populations are useful for linkage analysis using a variety of

techniques, including Mapping using Admixture Linkage Disequilibrium

and Transmission Disequilibrium Test. This extension of NIAAA research

on Choctaw American Indians will utilize the population structure in a

unique way to determine the genetic basis of alcoholism and related

psychiatric phenotypes. It will complement the current family and

epidemiological approaches. In combination, these different approaches

will yield one of the most comprehensive studies yet performed.

Moreover, this study recognizes the true population structure and

utilizes it to analytical advantage.

The annual burden estimates are as follows:

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Responses

Type and number of respondents per Total Hours Total hours

respondent responses

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Clients--700................................................ 1 700 4.0 2800

Total Number of Respondents................................. ........... 700 ........... ...........

Total Number of Responses................................... ........... 700 ........... ...........

Total Hours................................................. ........... 2800 ........... ...........

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Request for Comments

Comments are invited on: (a) whether the proposed collection is

necessary, including whether the information has practical use; (b)

ways to enhance the clarity, quality, and use of the information to be

collected; (c) the accuracy of the agency estimate of burden of the

proposed collection; and (d) ways to minimize the collection burden of

the respondents. Send written comments to Ms. Ronni Nelson, Laboratory

of Neurogenetics, Division of Intramural Clinical and Biological

Research, NIAAA, NIH, Park Bldg. Room 451, 12420 Parklawn Drive MSC

8110, Rockville, Maryland 20852.

FOR FURTHER INFORMATION: To request more information on the proposed

project or to obtain a copy of the data collection plans, contact Ms.

Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural

Clinical and Biological Research, NIAAA, Park Bldg. Room 451, 12420

Parklawn Drive MSC 8110, Rockville, Maryland 20852, or call non-toll-

free number (301) 443-5781.

COMMENTS DUE DATE: Comments regarding this information collection are

best assured of having their full effect if received on or before

September 2, 1997.

Dated: June 23, 1997.

Martin K. Trusty,

Executive Officer, NIAAA.

[FR Doc. 97-17199 Filed 6-30-97; 8:45 am]

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