Proposed Collection; Comment Request; Clinical, Laboratory, and Epidemiologic Characterization of Individuals at High Risk of Cancer

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health

Proposed Collection; Comment Request; Clinical, Laboratory, and

Epidemiologic Characterization of Individuals at High Risk of Cancer

SUMMARY: In compliance with the requirement of Section 3506(c)(2)(A) of

the Paperwork Reduction Act of 1995, for opportunity for public comment

on proposed extension of existing data collection projects, the

National Cancer Institute (NCI), the National Institutes of Health

(NIH) will publish periodic summaries of proposed projects to be

submitted to the Office of Management and Budget (OMB) for review and

approval.

PROPOSED COLLECTION: Title Clinical, Laboratory, and Epidemiologic

Characterization of Individuals at High Risk of Cancer. Type of

Information Collection Request: Extension of OMB No. 0925-0194

(Expiration date 01/31/97). Need and Use of Information Collection:

This ongoing research study will identify cancer-prone persons in order

to learn about cancer risk and cancer causes in individuals and

families. The primary objectives of this research study are to utilize

clinical, laboratory, and epidemiologic approaches in studies of

individuals and families at high risk of cancer to identify and further

characterize cancer susceptibility factors. Respondents are members of

families in which multiple cancers are thought to have occurred.

Information about the occurrence of cancer is collected and reviewed to

determine eligibility for further etiologic study. Participation is

entirely voluntary. The findings will lead to a better understanding of

the causes and risk factors for selected cancers, which may reduce

cancer incidence, and promote the earlier diagnosis of some cancers.

Frequency of Response: One time. Affected Public: Individuals or

households. Type of Respondents: Adults. The annual reporting burden is

as follows: Estimated Number of Respondents: 600 per year; Estimated

Number of Responses per Respondent: 1; Average Burden Hours Per

Response: .75; and Estimated Total Annual Burden Hours Requested: 450.

The annualized cost to respondent is estimated at: $4,500. There are no

Capital Costs to report. There are no Operating or Maintenance Costs to

report.

REQUEST FOR COMMENTS: Written comments and/or suggestions from the

public and affected agencies are invited on one or more of the

following points: (1) Whether the proposed collection of information is

necessary for the proper performance of the function of the

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agency, including whether the information will have practical utility;

(2) The accuracy of the agency's estimate of the burden of the proposed

collection of information, including the validity of the methodology

and assumptions used; (3) Ways to enhance the quality, utility, and

clarity of the information to be collected; and (4) Ways to minimize

the burden of the collection of information on those who are to

respond, including the use of appropriate automated, electronic,

mechanical, or other technological collection techniques or other forms

of information technology.

FOR FURTHER INFORMATION:To request more information on this project or

to obtain a copy of the data collection plans and instrument, write to

Dr. Margaret Tucker, Chief, Genetic Epidemiology Branch, National

Cancer Institute, NIH, Executive Plaza North, Room 439, 6130 Executive

Blvd., Bethesda, MD 20892, or call non-toll-free number (301) 496-4375,

or E-mail your request, including your address to:

[email protected]

COMMENTS DUE DATE: Comments regarding this information collection are

best assured of having their full effect if received on or before

February 14, 1997.

Dated: December 9, 1996.

Nancie L. Bliss,

OMB Project Clearance Liaison.

[FR Doc. 96-31781 Filed 12-13-96; 8:45 am]

BILLING CODE 4140-01-M