Proposed Collection, Comment Request; ``Alcoholism Prevalence and Gene/Environment Interactions in Native America Tribes (a 10 Tribe Study)'' and ``A Native American Tribe With Low Alcoholism Prevalence: Transmission Analysis, Linkage Analysis and Gene/Environment Interactions (a 1 Tribe Study)''

[Federal Register Volume 61, Number 127 (Monday, July 1, 1996)]

[Notices]

[Page 33937]

From the Federal Register Online via the Government Publishing Office [www.gpo.gov]

[FR Doc No: 96-16720]

[[Page 33937]]

National Institutes of Health

Proposed Collection, Comment Request; ``Alcoholism Prevalence and

Gene/Environment Interactions in Native America Tribes (a 10 Tribe

Study)'' and ``A Native American Tribe With Low Alcoholism Prevalence:

Transmission Analysis, Linkage Analysis and Gene/Environment

Interactions (a 1 Tribe Study)''

SUMMARY: In compliance with Section 3506 (c) (2) (A) of the Paperwork

Reduction Act of 1995, which provides for an opportunity for public

comment on proposed data collection projects, the National Institute on

Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health

(NIH) will publish periodic summaries of proposed projects to be

submitted to the Office of Management and Budget (OMB) for review and

approval.

PROPOSED COLLECTION: The Laboratory of Neurogenetics (LN), Division of

Intramural Clinical and Biological Research, NIAAA, intends to conduct

the study for ``Alcoholism Prevalence and Gene/Environment Interactions

in Native American Tribes (a 10 tribe study)'' and ``A Native American

Tribe with Low Alcoholism Prevalence: Transmission Analysis, Linkage

and Gene/Environment Intersactions (a 1 tribe study).''

The LN is authorized by Section 452 of Part G of Title IV of the

Public Health Service Act (42 USC 288) as amended by the NIH

Revitalization Act of 1993 (Pub. Law 103-43). The information proposed

for collection in both studies will be used by the NIAAA to define the

prevalence in alcoholism and associated problems in tribes in which the

rates of alcoholism have been reported to be widely divergent.

Additional information will be collected on severe trauma and stress,

alcohol availability and socioeconomic factors to identify how these

variables interact with hereditary factors in the development of

alcoholis and related problems. In the single tribe study, a large

pedigree (or a few large pedigrees) will be constructed in order to

address issues of transmission of alcoholism vulnerability, linkage to

chromosomally mapped DNA markers, and the issues of mutations in

candidate genes.

The annual burden estimates are as follows:

----------------------------------------------------------------------------------------------------------------

Responses

Type and number of respondents per Total Hours Total hours

respondent responses

----------------------------------------------------------------------------------------------------------------

Clients 3300................................................ 1 3300 6.0 19,800

----------------------------------------------------------------------------------------------------------------

Total Number of Respondents: 3,300 (1,100 per year)

Total Number of Responses: 3,300 (1,100 per year)

Total Hours: 19,800 (6,600 per year)

REQUEST FOR COMMENTS: Comments are invited on: (a) whether the proposed

collection is necessary, including whether the information has

practical use; (b) ways to enhance the clarity, quality, and use of the

information to be collected; (c) the accuracy of the agency estimate of

burden of the proposed collection; and (d) ways to minimize the

collection burden of the respondents. Send written comments to Ms.

Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural

Clinical and Biological Research, NIAAA, NIH, DANAC4 (Flow Labs), 12501

Washington Ave., Rockville, Maryland 20852.

FOR FURTHER INFORMATION :To request more information on the proposed

project or to obtain a copy of the data collection plans, contact Ms.

Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural

Clinical and Biological Research, NIAAA, DANAC4 (Flow Labs), 12501

Washington Ave., Rockville, Maryland 20852, or call non-toll-free

number (301) 443-5781.

COMMENTS DUE DATE: Comments regarding this information collection are

best assured of having their full effect if received on or before

August 30, 1996.

Dated: June 20, 1996.

Martin K. Trustry,

Executive Officer, NIAAA.

[FR Doc. 96-16720 Filed 6-28-96; 8:45 am]

BILLING CODE 4140-01-M