Availability of Draft Toxicological Profiles

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-88]

Availability of Draft Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),

Public Health Service (PHS), Department of Health and Human Services

(HHS).

ACTION: Notice of availability.

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SUMMARY: The Comprehensive Environmental Response, Compensation, and

Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments

and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9604(i)(3)] directs

the Administrator of ATSDR to prepare toxicological profiles of

priority hazardous substances and to revise and republish each

toxicological profile as necessary. This notice announces the

availability of 8 updated drafts and 2 new draft toxicological profiles

prepared by ATSDR for review and comment.

DATES: To ensure consideration, comments on these draft toxicological

profiles must be received on or before February 21, 1995. Comments

received after the close of the public comment period will be

considered at the discretion of ATSDR based upon what is deemed to be

in the best interest of the general public.

ADDRESSES: Requests for copies of the draft toxicological profiles or

comments regarding the draft toxicological profiles should be sent to

the attention of Ms. Kim Fears, Division of Toxicology, Agency for

Toxic Substances and Disease Registry, Mailstop E-29, 1600 Clifton

Road, NE., Atlanta, Georgia 30333.

Requests for the draft toxicological profiles must be in writing.

Please specify the profiled hazardous substance(s) you wish to receive.

ATSDR reserves the right to provide only one copy of each profile

requested, free of charge. In case of extended distribution delays,

requestors will be notified.

Written comments and other data submitted in response to this

notice and the draft toxicological profiles should bear the docket

control number ATSDR-88. Send one copy of all comments and three copies

of all supporting documents to the Division of Toxicology at the above

address by the end of the comment period. All written comments and

draft profiles will be available for public inspection at the ATSDR,

Building 4, Executive Park Drive, Atlanta, Georgia (not a mailing

address), from 8:00 a.m. until 4:30 p.m., Monday through Friday, except

for legal holidays.

Because all public comments regarding ATSDR toxicological profiles

are available for public inspection, no confidential business

information should be submitted in response to this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Kim Fears, Division of Toxicology,

Agency for Toxic Substances and Disease Registry, Mailstop E-29, 1600

Clifton Road, NE., Atlanta, Georgia 30333, telephone (404) 639-6304.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization

Act (SARA) (Pub. L. 99-499) amends the Comprehensive Environmental

Response, Compensation, and Liability Act (CERCLA or Superfund) (42

U.S.C. 9601 et seq.) by establishing certain responsibilities for the

ATSDR and the Environmental Protection Agency (EPA) with regard to

hazardous substances which are most commonly found at facilities on the

CERCLA National Priorities List (NPL). Among these statutory provisions

is that the Administrator of ATSDR prepare toxicological profiles for

substances included on the priority lists of hazardous substances.

These lists identified the 275 hazardous substances which both Agencies

determined pose the most significant potential threat to human health.

The availability of the revised priority list of 275 hazardous

substances was announced in the Federal Register on February 28, 1994

(59 FR 9486). For prior versions of the list of substances see Federal

Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988

(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR

42067); October 17, 1991 (56 FR 52166); and October 28, 1992 (57 FR

48801). CERCLA also requires ATSDR to assure the initiation of a

research program to fill data needs associated with the substances.

Section 104(i)(3) of CERCLA (42 U.S.C. 9604(i)(3)) outlines the

content of these profiles. Each profile is required to include an

examination, summary and interpretation of available toxicological

information and epidemiologic evaluations. This information and data

are to be used to ascertain the levels of significant human exposure

for the substance and the associated health effects. The profiles must

also include a determination of whether adequate information on the

health effects of each substance is available or in the process of

development. When adequate information is not available, ATSDR, in

cooperation with the National Toxicology Program (NTP), is required to

assure the initiation of a program of research designed to determine

these health effects.

Although key studies for each of the substances were considered

during the profile development process, this Federal Register notice

seeks to solicit any additional studies, particularly unpublished data

and ongoing studies, which will be evaluated for possible addition to

the profiles now or in the future.

The following draft toxicological profiles are expected to be

available to the public on or about October 17, 1994.

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Document and hazardous substance CAS No.

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1. Carbon Disulfide (UPDATE).............................. 75-15-0

2. Creosote (UPDATE)...................................... 8001-58-9

3. Diazinon............................................... 333-41-5

4. 1,2-Dichloroethene (trans/cis) (UPDATE)................ 156-60-5

.......................................................... 156-59-2

5. Endrin and Endrin Aldehyde (UPDATE).................... 72-20-8

.......................................................... 53494-70-5

6. Hexachlorobenzene (UPDATE)............................. 118-74-1

7. Methyl T-Butyl Ether................................... 1634-04-4

8. Selenium (UPDATE)...................................... 7782-49-2

9. 1,1,2,2-Tetrachloroethane (UPDATE)..................... 79-34-5

10. Toxaphene (UPDATE).................................... 8001-35-2

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All profiles issued as ``Drafts for Public Comment'' represent the

agency's best efforts to provide important toxicological information on

priority hazardous substances in compliance with the substantive and

procedural requirements of Section 104(i)(3) of CERCLA, as amended. As

in the past, we are seeking public comments and additional information

which may be used to supplement these profiles. ATSDR remains committed

to providing a public comment period for these documents as a means to

best serve public health and our clients.

Dated: October 17, 1994.

Claire V. Broome,

Deputy Administrator, Agency for Toxic Substances and Disease Registry.

[FR Doc. 94-26136 Filed 10-20-94; 8:45 am]

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