Availability of Draft Toxicological Profiles

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency For Toxic Substances and Disease Registry

[ATSDR-86]

Availability of Draft Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),

Public Health Service (PHS), Department of Health and Human Services

(HHS).

ACTION: Notice of availability.

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SUMMARY: This notice announces the availability of eight new draft

toxicological profiles on unregulated hazardous substances prepared for

the Department of Defense by ATSDR for review and comment.

DATES: To ensure consideration, comments on these draft toxicological

profiles must be received on or before December 12, 1994. Comments

received after the close of the public comment period will be

considered at the discretion of ATSDR based upon what is deemed to be

in the best interest of the general public.

ADDRESSES: Requests for copies of the draft toxicological profiles or

comments regarding the draft toxicological profiles should be sent to

the attention of Ms. Kim Fears, Division of Toxicology, Agency for

Toxic Substances and Disease Registry, Mailstop E-29, 1600 Clifton

Road, NE, Atlanta, Georgia 30333.

Requests for the draft toxicological profiles must be in writing.

Please specify the profiled hazardous substance(s) you wish to receive.

ATSDR reserves the right to provide only one copy of each profile

requested, free of charge. In case of extended distribution delays,

requestors will be notified.

Written comments and other data submitted in response to this

notice and the draft toxicological profiles should bear the docket

control number ATSDR-86. Send one copy of all comments and three copies

of all supporting documents to the Division of Toxicology at the above

address by the end of the comment period. All written comments and

draft profiles will be available for public inspection at the ATSDR,

Building 4, Executive Park Drive, Atlanta, Georgia (not a mailing

address), from 8:00 a.m. until 4:30 p.m., Monday through Friday, except

for legal holidays. Because all public comments regarding ATSDR

toxicological profiles are available for public inspection, no

confidential business information should be submitted in response to

this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Kim Fears, Division of Toxicology,

Agency for Toxic Substances and Disease Registry, Mailstop E-29, 1600

Clifton Road NE., Atlanta, Georgia 30333, telephone, (404) 639-6304.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization

Act (SARA) of 1986 (Public Law 99-499) amended the Comprehensive

Environmental Response, Compensation, and Liability Act (CERCLA or

Superfund). Section 211 of SARA also amended Title 10 of the U.S. Code,

creating the Defense Environmental Restoration Program. Section 2704(a)

of Title 10 of the U.S. Code directs the Secretary of Defense to notify

the Secretary of Health and Human Services of not less than 25 of the

most commonly found unregulated hazardous substances at defense

facilities. Each profile includes an examination, summary and

interpretation of available toxicological information and epidemiologic

evaluations. This information and data are used to ascertain the levels

of significant human exposure for the substance and the associated

health effects. The profiles include a determination of whether

adequate information on the health effects of each substance is

available or in the process of development. When adequate information

is not available, ATSDR, in cooperation with the National Toxicology

Program (NTP), may plan a program of research designed to determine

these health effects.

Although key studies for each of the substances were considered

during the profile development process, this Federal Register notice

seeks to solicit any additional studies, particularly unpublished data

and ongoing studies, which will be evaluated for possible addition to

the profiles now or in the future.

The following draft toxicological profiles are expected to be

available to the public on or about September 23, 1994.

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Document and hazardous substance CAS No.

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1. Di-N-Octylphthalate.................................... 117-84-0

2. Hexachloroethane....................................... 67-72-1

3. HMX.................................................... 2691-41-0

4. Hydraulic Fluids....................................... (1)

5. Hydrazines............................................. 302-01-2

1,1-Dimethylhydrazine................................... 57-14-7

1,2-Dimethylhydrazine................................... 540-73-8

Dimethylhydrazine....................................... 30260-66-3

6. Mineral-Based Crankcase Oil............................ 8002-05-9

7. Titanium Tetrachloride................................. 7550-45-0

8. White Phosphorus....................................... 7723-14-0

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\1\Various.

All profiles issued as ``Drafts for Public Comment'' represent the

agency's best efforts to provide important toxicological information on

priority hazardous substances. We are seeking public comments and

additional information which may be used to supplement these profiles.

ATSDR remains committed to providing a public comment period for these

documents as a means to best serve public health and our clients.

Dated: October 12, 1994.

Claire V. Broome,

Deputy Administrator, Agency for Toxic Substances and Disease Registry.

[FR Doc. 94-25689 Filed 10-17-94; 8:45 am]

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