[OPPTS-41041; FRL-4870-4]

DEPARTMENT OF ENERGY

[OPPTS-41041; FRL-4870-4]

Thirty-Fourth Report of the TSCA Interagency Testing Committee to

the Administrator; Receipt of Report and Request for Comments

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

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SUMMARY: The TSCA Interagency Testing Committee (ITC), established

under section 4(e) of the Toxic Substances Control Act (TSCA),

transmitted its Thirty-Fourth Report to the Administrator of EPA on May

17, 1994. As noted in this Report, which is included with this notice,

the ITC revised the Priority Testing List by: (1) changing a

recommendation for one chemical, white phosphorus, to a designation,

(2) recommending two chemicals, ethyl tert-butyl ether and tert-amyl

methyl ether, and (3) removing eight chemicals from the List. The eight

chemicals being removed from the List are: methyl methacrylate, diethyl

phthalate, N-phenyl-1-naphthylamine, acetophenone, phenol, N,N-

dimethylaniline, ethyl acetate, and 2,6-dimethylphenol. The Report

states the reasons for the removal of these chemicals from the List.

EPA invites interested persons to submit written comments on the

Report.

In addition, EPA is soliciting interested parties for participation

in or monitoring of a TSCA section 4 testing consent agreement

development process for white phosphorus that was designated for

amphibian, reptile, wild mammal, and aquatic plant acute toxicity

testing; and terrestrial plant uptake and translocation testing. EPA is

also inviting manufacturers and/or processors of white phosphorus who

wish to participate in testing negotiations for white phosphorus to

develop and submit testing agreement proposals to EPA.

EPA has already solicited interested parties in developing testing

agreements for ethyl tert-butyl ether and tert-amyl methyl ether (59 FR

18399, April 18, 1994).

DATES: Written comments on the 34th ITC Report should be submitted by

August 12, 1994. Written testing proposals must be received by

September 12, 1994. Written notice of interest in being designated an

``interested party'' to the development or monitoring of a consent

agreement for white phosphorus must be received by September 12, 1994.

Those submitting written testing proposals will be considered

``interested parties'' and do not have to submit separate written

notice. EPA will contact all ``interested parties'' and advise them of

meeting dates.

ADDRESSES: Send six copies of written submissions to: TSCA Public

Docket Office (7407), Office of Pollution Prevention and Toxics,

Environmental Protection Agency, Rm. B-607 NEM, 401 M St., SW.,

Washington, DC 20460. Submissions should bear the document control

number (OPPTS-41041; FRL-4870-4).

The public record supporting this action, including comments, is

available for public inspection in Rm. B-607 NEM at the address noted

above from 12 noon to 4 p.m., Monday through Friday, except legal

holidays.

FOR FURTHER INFORMATION CONTACT: Susan B. Hazen, Director,

Environmental Assistance Division (7408), Office of Pollution

Prevention and Toxics, Environmental Protection Agency, 401 M St., SW.,

Rm. E-543B, Washington, DC 20460, (202) 554-1404, TDD (202) 554-0551.

SUPPLEMENTARY INFORMATION: EPA has received the TSCA Interagency

Testing Committee's Thirty-Fourth Report to the Administrator.

I. Background

TSCA (Pub. L. 94-469, 90 Stat. 2003 et seq; 15 U.S.C. 2601 et seq.)

authorizes the Administrator of EPA to promulgate regulations under

section 4(a) requiring testing of chemicals and chemical groups in

order to develop data relevant to determining the risks that such

chemicals and chemical groups may present to health or the environment.

Section 4(e) of TSCA established the Interagency Testing Committee to

recommend chemicals and chemical groups to the Administrator of EPA for

priority testing consideration. Section 4(e) directs the ITC to revise

the TSCA section 4(e) Priority Testing List at least every 6 months.

The most recent revisions to this List are included in the ITC's

Thirty-Fourth Report. The Report was received by the Administrator on

May 17, 1994, and is included in this Notice. The Report changes a

recommendation for one chemical, recommends two chemicals, and removes

eight chemicals from the TSCA section 4(e) Priority Testing List.

II. Written and Oral Comments

EPA invites interested persons to submit detailed comments on the

ITC's Report. All submissions should bear the identifying docket number

(OPPTS-41041).

EPA invites interested persons to submit detailed comments on the

ITC's new recommendations. The Agency is interested in receiving

information concerning additional or ongoing health and safety studies

on the subject chemicals as well as information relating to the human

and environmental exposure to these chemicals.

A notice will be published at a later date in the Federal Register

adding the substances recommended in the ITC's ThirtyFourth Report to

the TSCA section 8(d) Health and Safety Data Reporting Rule (40 CFR

part 716), which requires the reporting of unpublished health and

safety studies on the listed chemicals.

III. Status of List

The ITC's Thirty-Fourth Report notes the change of a recommendation

for one chemical to a designation, the recommendation of two chemicals,

and the removal of eight chemicals from the Priority Testing List. The

current TSCA section 4(e) Priority Testing List contains 12 chemicals

and 12 chemical groups, with 2 chemical groups and 3 chemicals

designated for testing.

IV. Testing Consent Agreements

1. Solicitation of interested parties. EPA's procedures for

requiring the testing of chemical substances under section 4 of TSCA

include the adoption of enforceable consent agreements and the

promulgation of test rules. These processes are found at 40 CFR 790.20.

EPA has on numerous occasions been approached by chemical companies

interested in negotiating consent agreements for testing ITC chemicals

or chemical groups. As a result of these requests, EPA is now inviting

persons interested in participating in or monitoring negotiations on

the chemical designated in the Thirty-Fourth ITC Report to notify EPA

in writing. Those who respond to this solicitation by the deadline

established in this notice will have the status of ``interested

parties'' and will be afforded opportunities to participate in the

negotiation process. These ``interested parties'' will not incur any

obligations by being designated ``interested parties.''

2. Solicitation of testing proposals for consent agreement

negotiations. EPA is also now soliciting testing proposals for a

consent agreement to perform amphibian, reptile, wild mammal, and

aquatic plant acute toxicity testing; and terrestrial plant uptake and

translocation testing on white phosphorus. Following publication of

this notice, manufacturers and/or processors have 60 days to develop

and submit testing proposals that they wish EPA to consider as

candidates for consent agreement negotiations for white phosphorus.

Testing guidelines for the designated tests include: (1) Lemna Acute

Toxicity Test at 40 CFR 797.1160, (2) Plant Uptake and Translocation

Test at 40 CFR 797.2850, (3) Amphibian Acute Toxicity Test, (4)

Reptilian Acute Toxicity Test, (5) Wild Mammal Acute Toxicity Test.

These guidelines are available to the public through the TSCA Public

Docket Office and the Environmental Assistance Division listed above.

These guidelines should be reviewed before submitting any testing

proposals in response to this notice.

For additional technical information on these testing guidelines

contact Dr. Barnett Rattner, Department of The Interior, (301) 497-

5671.

All testing proposals submitted should describe the testing to be

performed and explain any deviations from the test protocols.

EPA will review the submissions and select the most promising

submissions as candidates for negotiation. Submissions that fully

address the ITC's concerns will have a higher chance of success than

those that do not fully address all data needs.

3. Negotiation of testing program and development of a testing

consent agreement. EPA will follow the negotiation procedures under 40

CFR 790.22, and to the extent feasible, the timetable outlined in 40

CFR part 790, appendix A to subpart B.

For additional information about process or negotiations contact

Frank Kover, Chief, Chemical Testing and Information Branch, (202) 260-

8130.

Authority: 15 U.S.C. 2603.

Dated: June 30, 1994.

Charles M. Auer,

Director, Chemical Control Division, Office of Pollution Prevention and

Toxics.

Thirty-Fourth Report of the TSCA Interagency Testing Committee to the

Administrator, U.S. Environmental Protection Agency

SUMMARY: This is the 34th Report of the TSCA Interagency Testing

Committee (ITC) to the Administrator of the U.S. Environmental

Protection Agency (EPA). The ITC is revising its Priority Testing List

by changing a recommendation for one chemical, white phosphorus, to a

designation for action by the Administrator within 12 months,

recommending two chemicals, ethyl tert-butyl ether and tert-amyl methyl

ether and by removing eight chemicals. White phosphorus is being

designated to meet the data needs of the Department of Interior (DOI);

discussions are ongoing with the Agency for Toxic Substances and

Disease Registry (ATSDR), the Department of Defense (DOD), and EPA to

coordinate their data needs with those of DOI. Ethyl tert-butyl ether

and tert-amyl methyl ether are being recommended for health effects

testing because EPA needs these data for ongoing assessments. Methyl

methacrylate and diethyl phthalate are being removed from the List

because dermal absorption rate data are available that are likely to

satisfy the data needs of the Occupational Health and Safety

Administration (OSHA). N-Phenyl-1-naphthylamine is being removed from

the List because studies reviewed by the ITC did not increase concerns

for cancer and the ITC's priorities do not include designating the

chemical at this time. Acetophenone, phenol, N,N-dimethylaniline, ethyl

acetate and 2,6-dimethylphenol are being removed from the List because

EPA proposed the testing designated by the ITC in its 27th Report in a

test rule that was published on November 22, 1993 (58 FR 61654).

I. Background

The TSCA Interagency Testing Committee (ITC) was established by

section 4(e) of the Toxic Substances Control Act (TSCA):

...to make recommendations to the Administrator respecting the

chemical substances and mixtures to which the Administrator should

give priority consideration for the promulgation of a rule for

testing under section 4(a).... At least every six months..., the

Committee shall make such revisions in the List as it determines to

be necessary and to transmit them to the Administrator together with

the Committee's reasons for the revisions...

(Public Law 94-469, 90 Stat. 2003 et seq., 15 U.S.C. 2601 et

seq.).

Since its creation in 1976, the ITC has submitted 33 semi-annual

Reports to the EPA Administrator transmitting the Priority Testing List

and its revisions. These Reports have been published in the Federal

Register (FR) and are available from the ITC. The ITC meets monthly and

produces its revisions with the help of staff and technical contract

support provided by EPA. ITC membership and support personnel are

listed at the end of this Report.

Following receipt of the ITC's Report and the addition of chemicals

to the Priority Testing List, the EPA's Office of Pollution Prevention

and Toxics adds these chemicals to TSCA section 8(a) and 8(d) rules

that require manufacturers, processors, and/or distributors of these

chemicals to submit production and exposure data (8a), and health and

safety studies (8d), within 2 months of the rules' effective date. The

submissions are indexed and maintained by EPA. The ITC reviews the 8(a)

and 8(d) information and other available data on chemicals and chemical

groups (e.g., TSCA section 8(e) ``substantial risk'' studies, ``For

Your Information'' (FYI) submissions to EPA and published papers) to

determine if revisions to the Priority Testing List are necessary.

Revisions can include changing a recommendation to a designation for

action by the Administrator within 12 months, modifying the recommended

testing, or removing the chemical or chemical group from the List.

II. Revisions to the TSCA Section 4(e) Priority Testing List

The ITC's revisions to its TSCA Section 4(e) Priority Testing List

are summarized in the following Table 1.

Table 1. Chemicals Designated, Recommended and Removed From the TSCA

Section 4(e) Priority Testing List

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CAS No. Chemical/Group Action Date

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7723-14-0........... White phosphorus.... Designate 5/94

Previously

Recommended

Chemical for

Amphibian,

Reptile, Wild

Mammal, and

Aquatic Plant

Acute Toxicity

Testing; and

Terrestrial Plant

Uptake and

Translocation

Testing.

637-92-3............ Ethyl tert-butyl Recommend for 5/94

ether. health effects

testing.

994-05-8............ Tert-amyl methyl Recommend for 5/94

ether. health effects

testing.

80-62-6............. Methyl methacrylate. Remove Previously 5/94

Recommended

Chemical.

84-66-2............. Diethyl phthalate... Remove Previously 5/94

Recommended

Chemical.

90-30-2............. N-Phenyl-1- Remove Previously 5/94

naphthylamine. Recommended

Chemical.

98-86-2............. Acetophenone........ Remove Previously 5/94

Designated

Chemical.

108-95-2............ Phenol.............. Remove Previously 5/94

Designated

Chemical.

121-69-7............ N,N-Dimethylaniline. Remove Previously 5/94

Designated

Chemical.

141-78-6............ Ethyl acetate....... Remove Previously 5/94

Designated

Chemical.

576-26-1............ 2,6-Dimethylphenol.. Remove Previously 5/94

Designated

Chemical.

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III. Rationale for the revisions

A. ITC's Activities During this Reporting Period

During the 6 months covered by this Report, November 1993 through

April 1994, the ITC reviewed the TSCA section 8(a) and section 8(d)

submissions and other available data for white phosphorus and N-phenyl-

1-naphthylamine and dermal absorption data for diethyl phthalate and

methyl methacrylate, and made decisions with respect to their

dispositions on the Priority Testing List.

B. Specific Rationales

1. Designated chemical -- White phosphorus--a. Background.

Thousands of ducks in wetlands at an artillery impact area have been

poisoned by white phosphorus. The Department of Interior (DOI) is

concerned about the persistence of white phosphorus in wetland

sediments, the adverse effects of white phosphorus on wildlife, and the

indirect effects of white phosphorus on endangered species that feed on

carcasses of white phosphorus-poisoned wildlife.

In November 1991, based on DOI's data needs, the ITC recommended

testing to determine the persistence of white phosphorus in surface

waters and sediments and the toxicity to migratory birds and other

wildlife (see the ITC's 29th Report in 56 FR 67424, December 30, 1991).

Since that recommendation, the DOI has considered these and other data

needs. Discussions at ITC meetings, are ongoing with the Agency for

Toxic Substances and Disease Registry (ATSDR), the Department of

Defense (DOD), and the U.S. Environmental Protection Agency (EPA) to

coordinate their data needs with those of DOI. Several Federal

Government organizations have past and ongoing activities that could

result in the identification of additional data needs for white

phosphorus and more ITC testing designations. Some of these activities

are described below.

ATSDR is drafting a toxicological profile on white phosphorus. DOD

is supporting studies on white phosphorus because it is detected in

wetlands on DOD munitions testing sites. In 1990, EPA published a

Drinking Water Health Advisory for white phosphorus (Ref. 20). In 1992

and 1993, EPA obtained 1991 and 1992 data under the Toxics Release

Inventory (TRI), indicating that during each of these years about

300,000 pounds of white phosphorus were released to land (Ref. 17).

These releases are an order of magnitude lower than reported for

previous years (56 FR 67424) and reflect, in part, more accurate record

keeping by white phosphorus manufacturers. In 1993, EPA and DOD

conducted 4 seminars on ``technologies for remediating sites

contaminated with explosive and radioactive wastes'' (Ref. 21). In

1993, EPA also prepared a handbook entitled ``Approaches for the

Remediation of Federal Sites Contaminated with Explosive and

Radioactive Wastes'' (Ref. 22). White phosphorus was extensively

discussed in the seminars and the handbook. EPA is making a

determination of whether there are health effects data needed for white

phosphorus under Title III of the Clean Air Act. ITC will coordinate

ATSDR, DOD and EPA data needs with those of DOI and determine if

additional testing needs to be designated in a future ITC report.

The Chemical Abstracts Service (CAS) has two Registry numbers for

white phosphorus: 7723-14-0, as a general number for white, yellow,

black and red phosphorus, and 12185-10-3 specifically for white

phosphorus. The ITC used CAS No. 7723-14-0 in the 29th Report, because

it is the most commonly used for white phosphorus. It is used to record

production volume and environmental release data as well as most

published and unpublished studies. In response to the ITC's 29th Report

testing recommendations, EPA promulgated TSCA section 8(a) and 8(d)

rules for CAS No. 7723-14-0 on March 12, 1993, and for CAS No. 12185-

10-3 on December 27, 1993. The manufacturers, processors and

distributors of white phosphorus submitted section 8(a) reports and

section 8(d) studies only for 7723-14-0. Therefore, the ITC is only

designating white phosphorus as CAS No. 7723-14-0 and requesting that

EPA remove CAS No. 12185-10-3 from the TSCA section 8(d) rule.

b. Designated testing. To meet the data needs of DOI, the ITC is

designating white phosphorus for amphibian, reptile, wild mammal and

aquatic plant acute toxicity testing, and terrestrial plant uptake and

translocation testing.

c. Rationale for designation. DOI reviewed the submitted section

8(a) and 8(d) data as well as TSCA section 8(e), FYI, and published

papers for white phosphorus. It continues to be concerned about the

persistence of white phosphorus in wetland sediments, adverse effects

on wildlife that feed on white phosphorus-contaminated sediments, and

the potential adverse effects on endangered species that feed on

carcasses of wildlife that die from white phosphorus poisoning.

Although DOI is working with DOD to conduct and coordinate testing and

field investigations of white phosphorus, DOI has data needs that are

not included in this coordinated, government-funded program. These

additional data are needed by DOI to assess the ecological risks posed

by white phosphorus.

d. Supporting information. DOI nominated white phosphorus to the

ITC in 1991 because persistence and ecotoxicity data were needed to

assess the ecological risks posed by white phosphorus. The results of

studies submitted under TSCA section 8(d) and section 8(e), other

relevant data, and ongoing activities are presented below along with

the specific rationales for the designated tests.

(1) Exposure information--production/use/disposal/exposure/release.

In 1990, approximately 700 million pounds of white phosphorus were

produced (Ref. 2). Based on 1991 and 1992 TRI data, about 300,000

pounds are released annually from production facilities (Ref. 17). The

amounts of white phosphorus released during munitions testing,

pesticides manufacturing and other uses is unknown to the ITC.

Every year since 1980, up to 3,000 waterfowl (dabbling ducks), 50

swans, and an undetermined number of shorebirds appear to have died

from white phosphorus poisoning at an artillery impact area in the

estuarine wetlands of Eagle River Flats, Cook Inlet, Alaska. This

wildlife mortality continues despite the fact that on September 10,

1991, the Assistant Secretary of the Army (Installations, Logistics,

and Environment) suspended the Army's firing of white phosphorus

munitions in wetland areas.

White phosphorus has been detected in water samples (0.013-0.069

g/L) from Eagle River Flats (Ref. 10). White phosphorus

particles have been visually identified and chemically-confirmed at

concentrations of 10 ppm in sediments (Refs. 11 and 23). White

phosphorus has been isolated from the gizzards of dead mallard ducks,

Anas platyrhynchos (Ref. 11). Exposure of at least a dozen avian

species has been documented through chemical detection of white

phosphorus in gizzard, liver, muscle, fat or skin (Refs. 11, 13, and

23).

White phosphorus contamination at artillery impact areas is

currently being investigated by Simmers et al. (Ref. 14). Sampling

results from 21 of the 23 DOD installations indicate that white

phosphorus was detected (detection limit of 1 g/kg) at seven

of the installations (Ref. 3).

(2) Chemical fate information. Degradation rates of white

phosphorus solutions have been characterized in an aqueous in vitro

test system (Ref. 4), and appear to be dependent on dissolved oxygen,

pH and temperature. Under aerobic conditions, solutions of white

phosphorus are rapidly oxidized (or possibly hydrolyzed or volatilized;

Ref. 15) and its concentration decreases monotonically with time (282

to 1762 g/L yielded a half-life of 3 hours for the initial 24

hour period). However, degradation rates are reduced at temperatures

below 22 deg.C and in closed (non-aerated) test systems. Under such

conditions, white phosphorus half-life increases from hours to weeks.

When sediments were tested in a modified aqueous in vitro test system,

degradation rates of white phosphorus were slower in sediment than in

water (Ref. 5).

White phosphorus in sediments at the estuarine wetlands of Eagle

River Flats, Alaska is often found as particulates, ranging in diameter

from 0.15 to 3.5 mm (corresponding to the size range of food items and

gizzard material selected by many species of waterfowl), and at

sediment depths of up to 30 cm (Ref. 10). White phosphorus particles

appear to be quite persistent in the saturated saline sediments of

Eagle River Flats, but volatilize as sediments dry below 20 percent

moisture (Ref. 23). Factors that affect persistence of white phosphorus

in sediments include sediment porosity, moisture content and

temperature, all of which interact to determine the rate of

sublimation. Oxygen may slow sublimation by the formation of oxidation

products around the particles that impose a diffusion barrier to white

phosphorus vapor. Using data on the dissolution rate of white

phosphorus particles in water (Ref. 15), Walsh (Ref. 23) estimated the

dissolution of a 1 mm diameter white phosphorus sphere to be 8 years.

The extent of particulate white phosphorus contamination in the United

States remains largely unknown.

The rate of oxidation of white phosphorus particles in aerated-soil

is highly variable depending on environmental conditions (Refs. 1, 12

and 24). Using a model to estimate the fate of white phosphorus

particles in soil, Spanggord et al. estimated that particles buried in

soil could persist for several years, and if an ``oxidized coat'' were

formed, particles could persist for thousands of years (Ref. 15).

These data demonstrate the persistence of white phosphorus in

sediments. Therefore, the ITC is not designating further chemical fate

testing of white phosphorus at this time.

(3) Health effects information. The ITC's 29th Report summarized

available health effects data for white phosphorus. These data indicate

that white phosphorus is highly toxic to humans and laboratory animals

(56 FR 67424; December 30, 1991). As noted in the summary of this 34th

Report, discussions are ongoing with ATSDR, DOD and EPA to coordinate

their data needs with those of DOI. The ITC is not designating further

health effects testing at this time because those discussions have not

been completed.

(4) Ecological effects information-- Acute and subchronic effects

(short-term). The ITC's 29th Report summarized laboratory and field

studies for white phosphorus. These studies indicated that white

phosphorus is highly toxic to aquatic organisms (56 FR 67424, December

30, 1991).

Thirty-day bioassays are currently being conducted by the U.S. Army

Environmental Hygiene Agency to measure the toxicity of white

phosphorus contaminated sediments from Eagle River Flats to the

crustacean, Hyallela azteca and the midge larve, Chironomus riparius

(Ref. 10).

The median lethal dose for adult male and juvenile mallard ducks

gavaged with white phosphorus dissolved in corn oil vehicle was 6.5 mg/

kg (Ref. 10). Signs of toxicity include slow rhythmic lateral head

shaking, and lethargy, followed by convulsions. Birds often succumb

within 1 to 2 hours, but in other instances may linger for up to 55

hours prior to death. Concentrations of white phosphorus in dosed

mallards exceed 0.25 g/g in fat, skin and liver (Refs. 10 and

11).

The acute median lethal dose of white phosphorus in female mallards

is being estimated by Sparling (Ref. 16). The females appear to be

slightly more tolerant than male and juvenile birds (LD50>10 mg/kg)

(Ref. 16). An estimation of the lowest observable effect level (LOEL)

will be determined by Sparling (Ref. 16) using white phosphorus pellets

without vehicle, because a corn oil vehicle may affect absorption and

toxicity.

Increasing evidence suggests the potential for widespread white

phosphorus pollution in wetlands. While white phosphorus toxicity data

have been or are being developed for aquatic and avian species that

inhabit wetlands. There are no white phosphorus toxicity data for

amphibians, reptiles, and wild mammals that frequent temperate zone

wetland habitats. In addition, some mammals, including furbearers

(e.g., mink), frequent wetlands and are known to be far more sensitive

to certain environmental pollutants (e.g., PCBs) than laboratory

rodents. For these reasons, DOI needs amphibian, reptile, and wild

mammal acute toxicity test data for its white phosphorus risk

assessment.

Based on limited available data and DOI's data needs, the ITC is

designating white phosphorus for amphibian, reptile, and wild mammal

acute toxicity testing.

Chronic (long-term) effects. The ITC's 29th Report described

laboratory studies that demonstrated the chronic toxicity of white

phosphorus to aquatic organisms (56 FR 67424, December 30, 1991).

Based on these data and ongoing DOI studies, the ITC is not

designating further chronic aquatic toxicity testing at this time.

Metabolism and pharmacokinetics. Data for laboratory mammals were

summarized in the ITC's 29th Report (56 FR 67424, December 30, 1991).

Recent studies suggest that acute white phosphorus toxicity in warm-

blooded animals may be due to the nonenzymatic metabolism of white

phosphorus to phosphine (Ref. 8).

A recent publication described the uptake and loss of white

phosphorus in American kestrels or sparrow hawks (Falco sparverius)

(Ref. 9). This study indicated that although uptake of white phosphorus

was rapid, bioaccumulation is limited in American kestrels because of

chemical or enzymatic degradation.

Uptake and depuration studies of white phosphorus administered to

mallards below the LD50 will be studied by Sparling (Ref. 16).

Pharmacokinetics will be studied by Sparling (Ref. 16) at various

intervals for a 10-day period in breast muscle, gizzard, abdominal fat,

skin, liver, pancreas and blood. Sparling (Ref. 16) will also study

histopathological and biochemical biomarkers of exposure.

Based on these data and ongoing DOI studies, the ITC is not

designating further metabolism and pharmacokinetic testing at this

time.

Reproductive effects. In rats, 75 g/kg/day of white

phosphorus reduced pregnancy rates (Ref. 6), increased death rates of

females in late gestation (Ref. 7), increased parturition-related

difficulties (Ref. 18), and increased the number of dead pups at birth

(Ref. 19). The birth defects caused by white phosphorus, and the

presence of white phosphorus in herring gull eggs collected in Eagle

River Flats (Ref. 8), suggest the need for reproductive effects studies

in birds. DOI is planning preliminary studies to investigate fertility

rates of male and female mallards repeatedly gavaged (chronic exposure)

with low doses of white phosphorus (Ref. 16).

Based on the studies conducted by Monsanto and planned DOI studies,

the ITC is not designating further reproductive effects testing at this

time.

Other ecological effects. Predation of ducks poisoned by white

phosphorus was systematically monitored at Eagle River Flats in the

spring and fall of 1991 (Ref. 13). Twenty-four instances of predation

of sick or dead dabbling ducks by bald eagles (Haliaetus

leucocephalus), herring gulls (Larus argentatus) and common ravens

(Corvus corax) were observed. Other predators, including northern

harrier (Circus cyaneus) and coyotes (Canis latrans) have been observed

to hunt over the Flats. Many decaying bald eagle carcasses have been

found at or near Eagle River Flats, and the single carcass tested was

positive for white phosphorus in fatty tissues (Refs. 10 and 13). Based

on these observations, and the risk assessment of Roebuck et al. (Ref.

13), there is considerable potential for secondary poisoning of

predators, including endangered species.

DOI will investigate secondary poisoning of predators (raptors and

other scavengers) using captive American kestrels fed northern bobwhite

quail chicks (Colinus virginianus) that had been gavaged with 1 mg/kg

pelletized white phosphorus for a 10-day period (Ref. 16). Mortality,

biochemical and histopathological biomarkers of toxicity, and white

phosphorus burdens in kestrels will be studied (Ref. 16).

Based on data published by Racine (Ref. 10) and Roebuck (Ref. 13)

and planned DOI studies, the ITC is not designating other ecological

effects testing at this time.

Bioconcentration and food chain transport. The 29th ITC Report

noted that bioconcentration of white phosphorus was studied in three

species of fish, six species of invertebrates and in two species of

seaweed (56 FR 67424; December 30, 1991). Fish and invertebrates have

been collected at Eagle River Flats by Racine for determination of

white phosphorus uptake (Ref. 10).

A recent study suggested that large predators such as bald eagles,

that have the ability to ingest whole gizzards of prey birds, could

bioaccumulate white phosphorus because the amount ingested could exceed

the degradation capacity (Ref. 9).

Few data are available on bioconcentration and food chain transport

of white phosphorus by plants. This data need concerns DOI because

white phosphorus has been detected in or on the roots of salt marsh

plants at Eagle River Flats (Ref. 10), and because many herbivorous

wildlife species could be exposed to, and be adversely affected by,

white phosphorus as a result of uptake and bioconcentration by plants.

Based on DOI's data needs, the ITC is designating white phosphorus

for aquatic plant toxicity and terrestrial plant uptake and

translocation testing.

2. Recommended chemicals -- Ethyl tert-butyl ether and tert-amyl

methyl ether-- a. Background. The ITC designated methyl tert-butyl

ether (MTBE) for health effects testing in its 20th Report because of

concerns for widespread human exposure to low level fugitive emissions

of MTBE at gasoline pumps and the need for chronic health effects data

(52 FR 19020; May 20, 1987). In response to the ITC's designation, EPA

and MTBE manufacturers negotiated a TSCA section 4 enforceable consent

agreement to develop pharmacokinetics, genotoxicity, subchronic

toxicity, reproductive effects, developmental toxicity, neurotoxicity,

and oncogenicity data (53 FR 10391, March 31, 1988). EPA is evaluating

the data from the completed MTBE testing program.

EPA needs health effects data for two other fuel oxygenates, ethyl

tert-butyl ether (ETBE) and tert-amyl methyl ether (TAME) and is

soliciting interest in developing testing agreements for these

chemicals (59 FR 18399, April 18, 1994).

b. Recommended testing. Ethyl tert-butyl ether and tert-amyl methyl

ether are being recommended for health effects testing because EPA

needs these data for ongoing assessments.

c. Rationale for recommendation. The use of ETBE and TAME to

augment or substitute for MTBE as fuel oxygenates and the health

effects data needs of ETBE and TAME are of concern to EPA and the ITC.

Therefore, the ITC is recommending testing to obtain TSCA section 8(d)

health and safety data on ETBE and TAME to support EPA's ongoing

assessments of the potential hazards/risks posed by these two chemical

substances. The ITC will share the data with EPA and other interested

U.S. Government organizations represented on the ITC and will review

these data to determine whether ETBE and TAME should be designated for

testing or removed from the Priority Testing List. The ITC is also

requesting data on acute toxicity of gasoline mixtures containing ETBE

and/or TAME. The ITC's process of recommending ETBE and TAME and then

making decisions following data review is consistent with the process

used for MTBE. MTBE was recommended in ITC's 19th Report (51 FR 41417,

November 14, 1986) and designated in ITC's 20th Report, following ITC's

review of voluntarily submitted and TSCA section 8(d) data.

d. Supporting information. EPA's recent Federal Register notice

provides supporting information (59 FR 18399, April 18, 1994).

The requirements of the Clean Air Act (CAA), 42 U.S.C. 7401-

7671q, along with reports of adverse human health effects associated

with the use of MTBE in winter-blend gasoline, have contributed to

the need for health effects testing of ETBE and TAME.

MTBE, ETBE, and TAME are fuel oxygenates which may be used to

satisfy the following requirements under the CAA. Under section

211(m) of the CAA, 42 U.S.C. 7545, States which have certain

attainment areas for carbon monoxide (CO) must require that any

gasoline sold or dispensed to ultimate customers in a specified

portion of the nonattainment area be blended, during wintertime, to

contain not less than 2.7 percent oxygen by weight (or applicable

percentage to meet the national primary air quality standard for CO

by the established attainment date). Under section 211(k),

reformulated gasoline must be used in nonattainment areas in nine

major metropolitan areas that are designated as ozone nonattainment

areas as well as various nonattainment ``opt-in'' areas by 1995 and

the oxygen content of this gasoline must be equal to or exceed 2

percent by weight. See Final Rule, Regulation of Fuels and Fuel

Additives: Standards for Reformulated and Conventional Gasoline,

February 16, 1994 (59 FR 7716). In addition, a proposed regulation

[by EPA's Office of Air and Radiation] would require that at least

30 percent of the oxygen content of reformulated gasoline come from

renewable oxygenates, which would include ETBE. See OAR/EPA Notice

of Proposed Rulemaking, regulation of Fuels and Additives: Renewable

Oxygenate Requirement for Reformulated Gasoline, December 27, 1993

(58 FR 68343).

Recently, there have been reports from the State of Alaska and

several areas in the lower 48 states of adverse human health effects

[(e.g., headache, nausea, general malaise)] associated with the use

of MTBE in winter-blend gasoline. (See Assessment of Potential

Health Risks of Gasoline Oxygenated with MTBE, Office of Research

and Development, U.S. EPA, November 1993.)

EPA believes that additional health effects test data on fuel

oxygenates are needed to allow government agencies and industry to

compare the health risks associated with the use of these substances

to augment or substitute for MTBE as a fuel oxygenate....

(1) Exposure information--production/use/disposal/exposure/release.

Estimates published in 1991 indicate that by 1995, annual production

volumes of ETBE and TAME are expected to exceed 26 million pounds

(Refs. 29 and 30) and 6 billion pounds (Ref. 35), respectively.

Estimates published in 1994 indicate that by 1995, about 335,000

barrels per day (32 billion pounds per year) of oxygenates will be

needed to meet oxygenated-and reformulated-fuel mandates (Ref. 28).

Consumer, occupational or environmental exposures to ETBE or TAME could

be substantial based on their use as fuel oxygenates.

(2) Physical and chemical information. ETBE has a molecular weight

of 102.18, a melting point of -97 deg.C (Ref. 26), a boiling point of

72 to 73 deg.C (Ref. 26), a log octanol/water partition coefficient of

1.58 (Ref. 31), a water solubility of 12,000 mg/L at 20 deg.C (Ref.

32), a vapor pressure of 130 mm Hg at 25 deg.C (Ref. 32), and a

Henry's Law constant of 1.45 x 10-3 atm-m3/mole at 25

deg.C (Ref. 34).

TAME has a molecular weight of 102.18, a boiling point of 85 to 86

deg.C (Ref. 25), a log octanol/water partition coefficient of 1.58

(Ref. 31), a water solubility of 11,500 mg/L at 20 deg.C (Ref. 32), a

vapor pressure of 75 mm Hg at 25 deg.C (Ref. 32), and a Henry's Law

Constant of 9.15 x 10-1 atm-m3/mole at 25 deg.C (Ref. 10).

(3) Chemical fate information. The estimated atmospheric half-life

of ETBE is 1.9 /days based on a hydroxyl radical concentration of 5 x

105 OH/cm3 and a rate constant of 8.5 x 10-12 atm-

m3/molecule-sec developed by Japar et al. (Ref. 29). The estimated

atmospheric half-life of TAME is 2.3 days based on a hydroxyl radical

concentration of 5 x 105 OH/cm3 and a rate constant of 7.91

x 10-12 atm-m3/molecule-sec estimated by Atkinson (Ref.

27).

The ITC is not recommending chemical fate testing, because it is

not a high priority data need at this time.

(4) Health effects information. The ITC is recommending health

effects testing to meet EPA's data needs.

(5) Ecological effects information. The ITC is not recommending

ecological effects testing, because it is not a high priority data need

at this time.

3. Removal of chemicals from the Priority Testing List-- a.Methyl

methacrylate and diethyl phthalate. In its 32nd Report, the ITC

designated methyl methacrylate (CAS No. 80-62-6) and diethyl phthalate

(CAS No. 84-66-2) for dermal absorption testing to meet the data needs

of the Occupational Safety and Health Administration (OSHA) (58 FR

38490, July 16, 1993). These chemicals were added to the Priority

Testing List as members of a 34-chemical group that had inadequate

dermal absorption rate data. OSHA nominated these chemicals to the ITC

to obtain data for OSHA to determine whether skin notations should be

assigned to these chemicals.

The ITC obtained dermal absorption rate data for methyl

methacrylate (Ref. 37) and diethyl phthalate (Ref. 36) that are likely

to meet OSHA's data needs. As a result, the ITC is removing methyl

methacrylate and diethyl phthalate from the Priority Testing List and

making the data publicly available by including the references in the

EPA docket for this 34th Report and transmitting the data to OSHA and

other interested U.S. Government organizations. As a result of finding

that these data are likely to meet OSHA's data needs, the ITC requested

EPA to remove these chemicals from its TSCA section 8(a) and/or section

8(d) rules before the May 10, 1994 reporting deadline. EPA removed

methyl methacrylate and diethyl phthalate from these TSCA section 8

rules on May 2, 1994 (59 FR 22519, May 2, 1994).

b. N-Phenyl-1-naphthylamine. In its 27th Report, the ITC

recommended N-phenyl-1-naphthylamine (CAS No. 90-30-2) for

carcinogenicity testing to meet the data needs of OSHA and for chemical

fate and ecological effects testing, because of ITC concerns for

environmental persistence and aquatic toxicity (56 FR 9534, March 6,

1991).

OSHA was concerned about potential occupational exposures to N-

phenyl-1-naphthylamine in hydraulic fluids and other mixtures, and the

potential carcinogenicity of this N-substituted aromatic amine. As

noted in ITC's 27th Report, OSHA's exposure concerns were based on

1981-1983 National Occupational Exposure Survey estimates that 96,478

workers were potentially exposed to N-phenyl-1-naphthylamine almost

exclusively through trade name products. After reviewing the TSCA

section 8(a) production and exposure data, ITC Members met with the

U.S. manufacturer of N-phenyl-1-naphthylamine. At the meeting and

during subsequent discussions, the ITC Members were provided with

estimates that 800 to 900 workers were exposed to technical grade N-

phenyl-1-naphthylamine during manufacturing and processing, and

specifications showing that concentrations of N-phenyl-1-naphthylamine

in formulated lubricants were generally less than four percent (Ref.

39).

ITC Members also reviewed the TSCA section 8(d) health and safety

studies and other toxicity data on N-phenyl-1-naphthylamine that were

obtained after the 27th Report was published. Most of these studies

were conducted on formulated products that did not specify the amount

of technical grade N-phenyl-1-naphthylamine in the product. The aquatic

toxicity studies indicated that formulated products containing N-

phenyl-1-naphthylamine were several orders of magnitude less toxic than

pure N-phenyl-1-naphthylamine, which, as reported in ITC's 27th Report,

was highly toxic to aquatic organisms and teratogenic to frogs (56 FR

9534, March 6, 1991). The biodegradation studies on formulated products

containing N-phenyl-1-naphthylamine confirmed its potential

environmental persistence. The health effects studies on formulated

products containing N-phenyl-1-naphthylamine did not suggest concerns

for carcinogenicity. The results from testing a structurally-related

chemical, N-phenyl-2-naphthylamine (CAS No. 135-88-6) by the National

Toxicology Program (NTP) showed it to be noncarcinogenic in rats and

mice (Ref. 40). Based on the available health effects data and

structure-activity considerations, there is no reason to believe that

N-phenyl-1-naphthylamine would have a greater carcinogenic potential

than N- phenyl-2-naphthylamine.

The ITC is removing N-phenyl-1-naphthylamine from the Priority

Testing List because the available data did not increase concern for

carcinogenicity, and the changing priorities of the ITC do not warrant

designating the chemical for testing at this time. This decision is

consistent with the April 1993 decision by the German Advisory

Committee on Existing Chemicals of Environmental Relevance (BUA) to not

conduct priority carcinogenicity investigations of N-phenyl-1-

naphthylamine (Ref. 38).

The ITC has completed its review of TSCA section 8(d) information

for N-phenyl-1-naphthylamine, and requests that EPA remove it from the

TSCA section 8(d) rule.

c. Acetophenone, phenol, N,N-dimethylaniline, ethyl acetate and

2,6-dimethylphenol. In its 27th Report, the ITC designated

acetophenone, phenol, N,N-dimethylaniline, ethyl acetate and 2,6-

dimethylphenol to meet EPA's data needs (56 FR 9534, March 6, 1991).

The ITC is removing these chemicals from the Priority Testing List

because EPA proposed a test rule on November 22, 1993 to implement the

testing (58 FR 61654, November 22, 1993).

References

(1) Bohn, H.I., Johnson, G.V. and Cliff, J.H. ``Detoxification

of white phosphorus in soil.'' Journal of Agricultural and Food

Chemistry. 18:1172-1173 (1970).

(2) CMR (Chemical Marketing Reporter). Chemical Profile:

Phosphorus. February 18, 1991.

(3) Daniels, J. D. Letter from James D. Daniels, Project

Engineer, U.S. Army Environmental Center, Aberdeen Proving Ground,

MD to Barnett A. Rattner, Deputy Chief, Branch of Environmental

Contaminants Research, Patuxent Wildlife Research Center, National

Biological Survey, Department of the Interior. Preliminary report of

results from the survey of range impact areas of 23 installations.

Dated February 28, 1994.

(4) Lai, M.G. ``Characterization of white phosphorus in water.

II. Degradation of white phosphorus in aqueous system.'' Naval

Surface Weapons Center, Silver Spring, MD. NSWC TR 79-5 (1979).

(5) Lai, M.G. ``Characterization of white phosphorus in water.

II. Behavior of white phosphorus in the water-sediment interface.''

Naval Surface Weapons Center, Silver Spring, MD. NSWC TR 81-87

(1981).

(6) Monsanto Company. ``Letter from Monsanto Company to the U.S.

EPA submitting information on elemental phosphorus with

attachments.'' TSCA 8e submission 88-890000065, microfiche number

OTS-051825, Washington, DC: OPPT, U.S. EPA (1989).

(7) Monsanto Company. ``A one-generation reproduction study in

rats with elemental phosphorus conducted by gavage in rats

(pathology report) with cover letter dated 020591.'' TSCA 8e

submission 87-910000168, microfiche number OTS-0518525-3,

Washington, DC: OPPT, U.S. EPA (1991).

(8) Nam, S.I., Roebuck, B.D., Walsh, M.E. and Racine, C.

``Biotransfer and accumulation of white phosphorus.'' Thirteenth

Annual Meeting of the Society of Environmental Toxicology and

Chemistry. Abstract 256 (1992).

(9) Nam, S.I., Roebuck, B.D. and Walsh, M.E. ``Uptake and loss

of white phosphorus in American kestrels.'' Environmental Toxicology

and Chemistry. 13:637-641 (1994).

(10) Racine, C.H. ``Eagle River Flats Progress Report.''

Department of the Army, Cold Regions Research and Engineering

Laboratory, Corps of Engineers, Hanover, New Hampshire. 18 pp.,

November 12, 1993.

(11) Racine, C.H., Walsh, M.E., Roebuck, B.D., Collins, C.M.,

Calkins, D., Reitsma, L., Buchli, P., and Goldfarb, G. ``White

phosphorus poisoning of waterfowl in an Alaskan salt marsh.''

Journal of Wildlife Diseases. 28:669-673 (1992).

(12) Rodrigues, A., Bohn, H.L. and Johnson, G.V. ``White

phosphorus as a phosphatic fertilizer.'' Soil Science Proceedings.

36:364-366 (1972).

(13) Roebuck, B.D., Walsh, M.E., Racine, C.H., Reitsma, L.,

Steele, B., and Nam, S. ``Predation of ducks poisoned by white

phosphorus: Exposure and risk to predators.'' Environmental

Toxicology and Chemistry. In Press.

(14) Simmers, J.W., Price, R.A., and Bird, S.T. ``Assessment of

white phosphorus contamination of artillery impact areas.''

Fourteenth Annual Meeting of the Society of Environmental Toxicology

and Chemistry. Abstract P509 (1993).

(15) Spanggord, R.J., Rewick, R., Chou, T.-W., Wilson, R.

Podoll, R.T., Mill, T. Parnas, T., Platz, R. and Roberts, D.L.

``Environmental fate of white phosphorus/felt and red phosphorus/

butyl rubber military screening smokes: Final report.'' SRI

International, Menlo Park, CA. ADA176922 (1985).

(16) Sparling, D.W. ``Occurrence of white phosphorus in food

chains within Eagle River Flats and its toxicity to waterfowl.''

U.S. Department of the Interior, National Biological Survey,

Patuxent Wildlife Research Center, Laurel, MD. Study Plan and

Modification 30030.23 (1994).

(17) TRI (Toxics Release Inventory). Database retrieval 3/21/94.

U.S. Environmental Protection Agency (1994).

(18) U.S. EPA. ``U.S. EPA Status Report: elemental phosphorus

with cover letter dated 112989.'' TSCA FYI submission FYI-OTS-0785-

0423, microfiche number OTS-0000423-1, Washington, DC: OPPT, U.S.

Environmental Protection Agency (1989a).

(19) U.S. EPA. ``U.S. EPA Status Report: elemental phosphorus

with cover letter dated 112989.'' TSCA 8e submission 8EHQ-0889-0820,

microfiche number OTS-0518525-1, Washington, DC: OPPT, U.S.

Environmental Protection Agency (1989b).

(20) U.S. EPA. ``White Phosphorus Health Advisory.'' U.S.

Environmental Protection Agency's Office of Drinking Water. NTIS PB

91-161025 (1990).

(21) U.S. EPA. ``Seminar on technologies for remediating sites

contaminated with explosive and radioactive wastes.'' U.S.

Environmental Protection Agency's Office of Research and Development

and Department of Defense. EPA/625/K-93/001 (1993).

(22) U.S. EPA. ``Handbook: approaches for the remediation of

Federal facility sites contaminated with explosive or radioactive

wastes.'' U.S. Environmental Protection Agency's Office of Research

and Development. EPA/625/R-93/013 (1993).

(23) Walsh, M.E. ``White phosphorus: An environmental

contaminant.'' Master of Science Thesis. Thayer School of

Engineering, Dartmouth College, Hanover, New Hampshire. 119 pp.

(1993).

(24) Warnock, R.E. ``Escape of elemental phosphorus from soil

applied as white phosphorus or the phosphorus-sulfur eutectic

solution.'' Journal of Environmental Quality 1:311-314 (1972).

(25) Aldrich. Catalog of Fine Chemicals 1990-1991 Milwaukee, WI:

Aldrich Chem CO. p. 98 (1990).

(26) Aldrich. Catalog of Fine Chemicals 1990-1991 Milwaukee, WI:

Aldrich Chem CO. p. 239 (1990).

(27) Atkinson, R. ``Kinetics and Mechanisms of the Gas-Phase

Reactions of the Hydroxyl Radical with Organic Compounds.'' Journal

of Physical Chemical Reference Data. D.R. Lide, Jr., Ed. American

Chemical Society. p. 142 (1989).

(28) Chemical Engineering. ``The drive for cleaner-burning

fuel.'' Chemical Engineering. p. 61, January 1994.

(29) Chemicalweek. ``ETBE gains presence in reformulated fuel.''

Chemicalweek. p. 9, July 31, 1991.

(30) Chemicalweek. ``Clean air drives the MTBE race.''

Chemicalweek. p. 22, July 31, 1991.

(31) CLOGP. CLOGP-PCGEMS-Graphic Exposure Modeling System.

CLOGP, U.S.EPA (1986).

(32) Evans, T.W. Edlund, K.R. ``Tertiary Alkyl Ethers

Preparation and Properties.'' 1ndustrial and Engineering Chemistry.

28:1186 (1936).

(33) Japar, S.M., Wallington, T.J., Rudy, S.J., Chang, T.Y.

``Ozone-Forming Potential of a Series of Oxygenated Organic

Compounds. Environmental Science Technology. 25:415-420 (1991).

(34) Lyman, W.J., Reehl, W.F., and Rosenblatt, D.H. Handbook of

Chemical Property Estimation Methods. Environmental Behavior of

Organic Compounds. Washington, DC: American Chemical Society. pp. 4-

9, 5-4, 5-10, 7-4, 7-5, 15-15 to 15-32 (1990).

(35) NFR. ``Over half-million B/D of oxygenate may be needed to

supply demand due to CAA.'' New Fuels Report. p. 12, February 25,

1991.

(36) Scott, R.C., Dugard, P.H., Ramsey, J.D. and Rhodes, C. ``1n

vitro absorption of some o-phthalate diesters through human and rat

skin.'' Environmental Health Perspectives. 74:223-227 (1987).

(37) Zeneca. ``Methyl methacrylate: 1n vitro absorption through

human epidermis.'' Zeneca Central Toxicology Laboratory Report No.

CTL/P/4025 provided by the Methacrylate Producers Association,

Washington, D.C. (1993).

(38) BUA. ``N-phenyl-1-naphthylamine, BUA-Stoffbericht 113,

Stand: April 1993 (In German).'' BUA, Stuttgart (1993).

(39) Carlton, B.D. September 7, 1993 letter from Dr. Betsy D.

Carlton, Rhone-Poulenc to Dr. John D. Walker, TSCA Interagency

Testing Committee. Rhone-Poulenc, Research Triangle Park, N.C.

(1993).

(40) NTP (National Toxicology Program). ``Toxicology and

carcinogenesis studies of N- phenyl-2-napthylamine (CAS No. 135-88-

6) in F344/N rats and B6C3F1 mice (feed studies).'' NTP TR 333.

Research Triangle Park, NC: U.S. Department of Health and Human

Services, National Institutes of Health (January 1988).

IV. The TSCA Section 4(e) Priority Testing List, as Revised (May

1994)

The TSCA Section 4(e) Priority Testing List (May 1994)

------------------------------------------------------------------------

Report Date Chemical/Group Action

------------------------------------------------------------------------

23.... November 1988....... Butyraldehyde....... Recommended

23.... November 1988....... Tetrakis(2- Recommended with

chloroethyl)ethylen intent-to-designate

e diphosphate.

Tris(1,3-dichloro-2-

propyl) phosphate.

Tris(1-chloro-2-

propyl) phosphate.

Tris(2-chloro-1-

propyl) phosphate.

Tris(2-chloroethyl)-

phosphate.

26.... May 1990............ Isocyanates......... Recommended with

intent-to-designate

27.... November 1990....... Aldehydes........... Recommended with

intent-to-designate

27.... November 1990....... Sulfones............ Recommended

27.... November 1990....... Substantially Recommended

produced chemicals

in need of

subchronic toxicity

testing.

28.... May 1991............ Acetone............. Designated

28.... May 1991............ Thiophenol.......... Designated

28.... May 1991............ m-Dinitrobenzene.... Recommended

28.... May 1991............ Cyanoacrylates...... Recommended

29.... November 1991....... Alkyl-, bromo-, Recommended

chloro-,

hydroxymethyl

diaryl ethers.

30.... May 1992............ Siloxanes........... Recommended

30.... May 1992............ Chloroalkyl Recommended

phosphates.

31.... January 1993........ OSHA chemicals with Designated

no dermal toxicity

data.

31.... January 1993........ Propylene glycol Recommended

ethers and esters

(revised).

31.... January 1993........ Methyl ethylene Recommended

glycol ethers and

esters (revised).

32.... May 1993............ OSHA chemicals with Designated

insufficient dermal

absorption data.

34.... May 1994............ White phosphorus.... Designated

34.... May 1994............ Ethyl tert-butyl Recommended

ether.

34.... May 1994............ Tert-amyl methyl Recommended

ether.

------------------------------------------------------------------------

The following table list the members of the TSCA Interagency

Testing Committee.

Statutory Organizations and Their Representatives

Council on Environmental Quality

Elisabeth Blaug, Member

Department of Commerce

Edward White, Member

Willie E. May, Alternate

Environmental Protection Agency

David R. Williams, Member

Lois Dicker, Alternate

National Cancer Institute

Thomas P. Cameron, Member

Richard Adamson, Alternate

National Institute of Environmental Health Sciences

Errol Zeiger, Member

National Institute for Occupational Safety and Health

Robert W. Mason, Member

Henryka Nagy, Alternate

National Science Foundation

Linda Duguay, Member

Occupational Safety and Health Administration

Christine Whittaker, Member, Chair

Liaison Organizations and Their Representatives

Agency for Toxic Substances and Disease Registry

William Cibulas, Member

Consumer Product Safety Commission

Val Schaeffer, Member

Lakshmi C. Mishra, Alternate

Department of Agriculture

Donald Derr, Member

Clifford Rice, Alternate

Department of Defense

David A. Macys, Member

James N. McDougal, Alternate

Department of the Interior

Barnett A. Rattner, Member

Food and Drug Administration

Edwin J. Matthews, Member

Raju Kammula, Alternate

National Library of Medicine

Vera Hudson, Member

National Toxicology Program

Victor A. Fung, Member

Counsel

Mary Ellen Levine, Office of General Counsel, EPA

Technical Support Contractor

Syracuse Research Corporation

Committee Staff

John D. Walker, Executive Director

Norma S.L. Williams, Executive Assistant, TSCA Interagency

Testing Committee U.S. EPA/OPPT (MC/7401) 401 M St., SW.,

Washington, DC 20460, (202) 260-1825, Fax (202) 260-1764

[FR Doc. 94-16983 Filed 7-12-94; 8:45 am]

BILLING CODE 6560-50-F