Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles
Federal RegisterMar 31, 2010
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-259]
Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles
AGENCY:
Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).
ACTION:
Request for comments on the proposed substances to be evaluated for Set 24 toxicological profiles.
SUMMARY:
This notice announces the list of proposed substances that will be evaluated for Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) Set 24 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public comments on the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the nomination of any additional, substances, not on this list, that may have public health implications.
DATES:
Nominations must be submitted within 30 days of the publication of this notice.
ADDRESSES:
Nominations may be submitted electronically. Refer to the section
Submission of Nominations
(following) for the specific address.
FOR FURTHER INFORMATION CONTACT:
For further information, contact: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, F-62, Atlanta, GA, 30333; telephone: (770) 488-3313; or e-mail:
jbtaylor@cdc.gov.
SUPPLEMENTARY INFORMATION:
The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601
et seq.
] amended the CERCLA (or Superfund) [42 U.S.C. 9601
et seq.
] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances most commonly found at facilities on the CERCLA NPL. Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This identifies 275 hazardous substances that ATSDR and EPA have determined pose the most significant potential threat to human health (
http://www.atsdr.cdc.gov/cercla/07list.html
). The availability of the revised list of the 275 priority substances was announced in the
Federal Register
on March 6, 2008 (73 FR 12178). For prior versions of the list of substances, see
Federal Register
notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); and November 7, 2003 (68 FR 63098), December 7, 2005 (70 FR 72840).
Proposed Substances To Be Evaluated for Set 24 Toxicological Profiles
Each year, ATSDR develops a list of substances to be considered for toxicological profile development. This list is compiled from ATSDR's Priority List of Hazardous Substances and from previously nominated substances of public health concern. The following list of 240 proposed substances will be considered for Set 24 Toxicological Profile development.
Substances
CAS Nos.
1
METHANE
000074-82-8
2
BROMODICHLOROETHANE
000683-53-4
3
1,2,3-TRICHLOROBENZENE
000087-61-6
4
POLONIUM-210
013981-52-7
5
LEAD-210
014255-04-0
6
NEPTUNIUM-237
013994-20-2
7
S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE
000078-48-8
8
BROMINE
007726-95-6
9
DICOLFOL
000115-32-2
10
PARATHIION
000056-38-2
11
TRICHLOROFLUOROETHANE
027154-33-2
12
TRIFLURALIN
000152-09-8
13
PENTACHLOROBENZENE
000608-93-5
14
TRICHLOROETHANE
025323-89-1
15
PALLADIUM
007440-05-3
16
DIBENZOFURAN
000132-64-9
17
2,4-DIMETHYLPHENOL
000105-67-9
18
TETRACHLOROETHANE
025322-20-7
19
BIS(2-METHOXYETHYL)PHTHALATE
034006-76-3
20
BUTYL BENZYL PHTHALATE
000085-68-7
21
1,2,4-TRICHLOROBENZENE
000120-82-1
22
NITRITE
014797-65-0
23
NITRATE
014797-55-8
24
POTASSIUM-40
013966-00-2
25
THORIUM-227
015623-47-9
26
PHORATE
000298-02-2
27
DIMETHOATE
000060-51-5
28
ACTINIUM-227
014952-40-0
29
STROBANE
008001-50-1
30
4-AMINOBIPHENYL
000092-67-1
31
ARSINE
007784-42-1
32
NALED
000300-76-5
33
ETHOPROP
013194-48-4
34
CARBOPHENOTHION
000786-19-6
35
2,4-D ACID
000094-75-7
36
DIURON
000330-54-1
37
BUTYLATE
002008-41-5
38
DIMETHYL FORMAMIDE
000068-12-2
39
DICHLOROBENZENE
025321-22-6
40
ETHYL ETHER
000060-29-7
41
DICHLOROETHANE
001300-21-6
42
PHOSPHINE
007803-51-2
43
TRICHLOROBENZENE
012002-48-1
44
PENTAERYTHRITOL TETRANITRATE
000078-11-5
45
BIS(2-ETHYLHEXYL)ADIPATE
000103-23-1
46
CARBAZOLE
000086-74-8
47
METHYL ISOBUTYL KETONE
000108-10-1
48
CARBARYL
000063-25-2
49
MERCURY
007439-97-6
50
METHYLMERCURY
022967-92-6
51
MERCURIC CHLORIDE
007487-94-7
52
POLYCHLORINATED BIPHENYLS
001336-36-3
53
AROCLOR 1254
011097-69-1
54
AROCLOR 1260
011096-82-5
55
AROCLOR 1248
012672-29-6
56
AROCLOR 1242
053469-21-9
57
AROCLOR
012767-79-2
58
AROCLOR 1221
011104-28-2
59
AROCLOR 1016
012674-11-2
60
AROCLOR 1232
011141-16-5
61
AROCLOR 1240
071328-89-7
62
TETRACHLOROBIPHENYL
026914-33-0
63
POLYCYCLIC AROMATIC HYDROCARBONS
130498-29-2
64
BENZO(A)PYRENE
000050-32-8
65
BENZO(B)FLUORANTHENE
000205-99-2
66
DIBENZO(A,H)ANTHRACENE
000053-70-3
67
BENZO(A)ANTHRACENE
000056-55-3
68
BENZO(K)FLUORANTHENE
000207-08-9
69
BENZOFLUORANTHENE
056832-73-6
70
FLUORANTHENE
000206-44-0
71
CHRYSENE
000218-01-9
72
ACENAPHTHENE
000083-32-9
73
INDENO(1,2,3-CD)PYRENE
000193-39-5
74
BENZOPYRENE
073467-76-2
75
PHENANTHRENE
000085-01-8
76
PYRENE
000129-00-0
77
FLUORENE
000086-73-7
78
ANTHRACENE
000120-12-7
79
BENZO(A)FLUORANTHENE
000203-33-8
80
BENZO(GHI)PERYLENE
000191-24-2
81
ACENAPHTHYLENE
000208-96-8
82
BENZO(J)FLUORANTHENE
000205-82-3
83
BENZO(E)PYRENE
000192-97-2
84
BENZOPERYLENE
011057-45-7
85
BENZO(B)ANTHRACENE
000092-24-0
86
DIBENZ(A,J)ANTHRACENE
000224-41-9
87
BENZO(GHI)FLUORANTHENE
000203-12-3
88
1-METHYLPYRENE
002381-21-7
89
CHLOROFORM
000067-66-3
90
DDT, P,P′-
000050-29-3
91
DDE, P,P′-
000072-55-9
92
DDD, P,P′-
000072-54-8
93
DDT, O,P′-
000789-02-6
94
DDD, O,P′-
000053-19-0
95
DDE, O,P′-
003424-82-6
96
TRICHLOROETHYLENE
000079-01-6
97
DIELDRIN
000060-57-1
98
ALDRIN
000309-00-2
99
CHLORDANE
000057-74-9
100
CIS-CHLORDANE
005103-71-9
101
TRANS-CHLORDANE
005103-74-2
102
OXYCHLORDANE
027304-13-8
103
GAMMA-CHLORDENE
056641-38-4
104
CHLORDANE, TECHNICAL
012789-03-6
105
ALPHA-CHLORDENE
056534-02-2
106
NONACHLOR, TRANS-
039765-80-5
107
NONACHLOR, CIS-
005103-73-1
108
CHLORDENE
003734-48-3
109
HEXACHLOROBUTADIENE
000087-68-3
110
COAL TAR CREOSOTE
008001-58-9
111
COAL TARS
008007-45-2
112
DDD, P,P′-
000072-54-8
113
COAL TAR PITCH
065996-93-2
114
BENZIDINE
000092-87-5
115
TOXAPHENE
008001-35-2
116
TETRACHLOROETHYLENE
000127-18-4
117
1,2-DIBROMOETHANE
000106-93-4
118
DISULFOTON
000298-04-4
119
3,3′-DICHLOROBENZIDINE
000091-94-1
120
ENDRIN
000072-20-8
121
ENDRIN KETONE
053494-70-5
122
ENDRIN ALDEHYDE
007421-93-4
123
BERYLLIUM
007440-41-7
124
1,2-DIBROMO-3-CHLOROPROPANE
000096-12-8
125
DIBROMOCHLOROPROPANE
067708-83-2
126
PENTACHLOROPHENOL
000087-86-5
127
DI-N-BUTYL PHTHALATE
000084-74-2
128
ENDOSULFAN
000115-29-7
129
ENDOSULFAN SULFATE
001031-07-8
130
ENDOSULFAN, ALPHA
000959-98-8
131
ENDOSULFAN, BETA
033213-65-9
132
METHOXYCHLOR
000072-43-5
133
METHANE
000074-82-8
134
TOLUENE
000108-88-3
135
2-HEXANONE
000591-78-6
136
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN
001746-01-6
137
HEXACHLORODIBENZO-P-DIOXIN
034465-46-8
138
HEPTACHLORODIBENZO-P-DIOXIN
037871-00-4
139
TETRACHLORODIBENZO-P-DIOXIN
041903-57-5
140
PENTACHLORODIBENZO-P-DIOXIN
036088-22-9
141
1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN
035822-46-9
142
OCTACHLORODIBENZO-P-DIOXIN
003268-87-9
143
1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN
057653-85-7
144
1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN
039227-28-6
145
1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN
019408-74-3
146
1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN
040321-76-4
147
DI(2-ETHYLHEXYL)PHTHALATE
000117-81-7
148
1,1-DICHLOROETHENE
000075-35-4
149
METHYLENE CHLORIDE
000075-09-2
150
BROMODICHLOROETHANE
000683-53-4
151
1,2-DICHLOROETHANE
000107-06-2
152
2,4,6-TRICHLOROPHENOL
000088-06-2
153
TETRACHLOROPHENOL
025167-83-3
154
2,4-DICHLOROPHENOL
000120-83-2
155
2,4,5-TRICHLOROPHENOL
000095-95-4
156
2-CHLOROPHENOL
000095-57-8
157
2,3,4,5-TETRACHLOROPHENOL
004901-51-3
158
2,3,5,6-TETRACHLOROPHENOL
000935-95-5
159
2,3,4,6-TETRACHLOROPHENOL
000058-90-2
160
4-CHLOROPHENOL
000106-48-9
161
CHLOROPHENOL
025167-80-0
162
2,4-DINITROPHENOL
000051-28-5
163
BIS(2-CHLOROETHYL) ETHER
000111-44-4
164
ASBESTOS
001332-21-4
165
CHRYSOTILE ASBESTOS
012001-29-5
166
AMOSITE ASBESTOS
012172-73-5
167
HEXACHLOROBENZENE
000118-74-1
168
2,4-DINITROTOLUENE
000121-14-2
169
DINITROTOLUENE
025321-14-6
170
2,6-DINITROTOLUENE
000606-20-2
171
RADIUM-226
013982-63-3
172
RADIUM
007440-14-4
173
RADIUM-228
015262-20-1
174
RADIUM-224
013233-32-4
175
ETHION
000563-12-2
176
THORIUM
007440-29-1
177
THORIUM-230
014269-63-7
178
THORIUM-228
014274-82-9
179
4,6-DINITRO-O-CRESOL
000534-52-1
180
CHLOROBENZENE
000108-90-7
181
N-NITROSODI-N-PROPYLAMINE
000621-64-7
182
1,2,3-TRICHLOROBENZENE
000087-61-6
183
POLONIUM-210
013981-52-7
184
CHLORPYRIFOS
002921-88-2
185
NEPTUNIUM-237
013994-20-2
186
CHLORDECONE
000143-50-0
187
MIREX
002385-85-5
188
S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE
000078-48-8
189
BROMINE
007726-95-6
190
DICOFOL
000115-32-2
191
PARATHION
000056-38-2
192
SELENIUM
007782-49-2
193
TRICHLOROFLUOROETHANE
027154-33-2
194
TRIFLURALIN
001582-09-8
195
4,4'-METHYLENEBIS(2-CHLOROANILINE)
000101-14-4
196
PENTACHLOROBENZENE
000608-93-5
197
1,1-DICHLOROETHANE
000075-34-3
198
1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN
039001-02-0
199
HEPTACHLORODIBENZOFURAN
038998-75-3
200
2,3,4,7,8-PENTACHLORODIBENZOFURAN
057117-31-4
201
HEXACHLORODIBENZOFURAN
055684-94-1
202
PENTACHLORODIBENZOFURAN
030402-15-4
203
2,3,7,8-TETRACHLORODIBENZOFURAN
051207-31-9
204
DIBENZOFURANS, CHLORINATED
042934-53-2
205
1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN
067562-39-4
206
1,2,3,7,8,9-HEXACHLORODIBENZOFURAN
072918-21-9
207
TETRACHLORODIBENZOFURAN
030402-14-3
208
1,2,3,6,7,8-HEXACHLORODIBENZOFURAN
057117-44-9
209
1,2,3,4,7,8-HEXACHLORODIBENZOFURAN
070648-26-9
210
2,3,4,6,7,8-HEXACHLORODIBENZOFURAN
060851-34-5
211
1,2,3,7,8-PENTACHLORODIBENZOFURAN
057117-41-6
212
1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN
055673-89-7
213
1,1,2-TRICHLOROETHANE
000079-00-5
214
HEXACHLOROCYCLOPENTADIENE
000077-47-4
215
1,2-DIPHENYLHYDRAZINE
000122-66-7
216
1,2-DICHLOROETHENE, TRANS-
000156-60-5
217
1,2-DICHLOROETHYLENE
000540-59-0
218
1,2-DICHLOROETHENE, CIS-
000156-59-2
219
CARBON DISULFIDE
000075-15-0
220
PALLADIUM
007440-05-3
221
CHLOROETHANE
000075-00-3
222
ACETONE
000067-64-1
223
DIBENZOFURAN
000132-64-9
224
2,4-DIMETHYLPHENOL
000105-67-9
225
CHLOROMETHANE
000074-87-3
226
BIS(2-METHOXYETHYL) PHTHALATE
034006-76-3
227
BUTYL BENZYL PHTHALATE
000085-68-7
228
N-NITROSODIMETHYLAMINE
000062-75-9
229
1,2,4-TRICHLOROBENZENE
000120-82-1
230
N-NITROSODIPHENYLAMINE
000086-30-6
231
2-BUTANONE
000078-93-3
232
FLUORINE
007782-41-4
233
HYDROGEN FLUORIDE
007664-39-3
234
FLUORIDE ION
016984-48-8
235
AMMONIA
007664-41-7
236
COPPER
065357-62-2
237
CHLORINE DIOXIDE
010049-04-4
238
PBBs
059536-65-1
239
PBDEs
001163-19-5
240
SYNTHETIC VITREOUS FIBERS
NONE
Submission of Nominations for the Evaluation Set 24 Proposed Substances:
Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the nominator, including full name, title, affiliation, e-mail address, and telephone number.
ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances to be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the
Selection Criteria
announced in the
Federal Register
on May 7, 1993 (87 FR 27288).
Submission of Comments:
Submit comments via e-mail at:
tpcandidatecomments@cdc.gov.
Please include “Set 24” in the subject line of the e-mail. Or, mail to: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, MS F-62, Atlanta, GA 30333; e-mail:
jbtaylor@cdc.gov.
Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time and resources permit.
Dated: March 26, 2010.
Ken Rose,
Associate Director, Office of Policy, Planning and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.
[FR Doc. 2010-7169 Filed 3-30-10; 8:45 am]
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