# 49 CFR § 392.4: Drugs and other substances

> Federal · Regulations · In force

URL: https://www.frixlaw.com/law-library/statutes/ecfr-49-392.4

## Section

- **Citation:** 49 CFR § 392.4
- **Heading:** Drugs and other substances
- **Jurisdiction:** Federal
- **Kind:** Regulations
- **Status:** In force
- **Text as of:** September 22, 2026
- **Source:** Publisher's official text
- **Location:** Title 49—Transportation > Subtitle B—Other Regulations Relating to Transportation > CHAPTER III—FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION > SUBCHAPTER B—FEDERAL MOTOR CARRIER SAFETY REGULATIONS > PART 392—DRIVING OF COMMERCIAL MOTOR VEHICLES > Subpart A—General

## Text

(a) No driver shall be on duty and possess, be under the influence of, or use, any of the following drugs or other substances:
(1) Any 21 CFR 1308.11 Schedule I substance;
(2) An amphetamine or any formulation thereof (including, but not limited, to “pep pills,” and “bennies”);
(3) A narcotic drug or any derivative thereof; or
(4) Any other substance, to a degree which renders the driver incapable of safely operating a motor vehicle.
(b) No motor carrier shall require or permit a driver to violate paragraph (a) of this section.
(c) Paragraphs (a) (2), (3), and (4) do not apply to the possession or use of a substance administered to a driver by or under the instructions of a licensed medical practitioner, as defined in § 382.107 of this subchapter, who has advised the driver that the substance will not affect the driver's ability to safely operate a motor vehicle.
(d) As used in this section, “possession” does not include possession of a substance which is manifested and transported as part of a shipment.
[61 FR 9567, Mar. 8, 1996, as amended at 62 FR 37153, July 11, 1997]

## Nearby sections

- [49 CFR § 392.1 § 392.1 Scope of the rules in this part.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.1.md)
- [49 CFR § 392.2 § 392.2 Applicable operating rules.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.2.md)
- [49 CFR § 392.3 § 392.3 Ill or fatigued operator.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.3.md)
- [49 CFR § 392.4 § 392.4 Drugs and other substances.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.4.md)
- [49 CFR § 392.5 § 392.5 Alcohol prohibition.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.5.md)
- [49 CFR § 392.6 § 392.6 Schedules to conform with speed limits.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.6.md)
- [49 CFR § 392.7 § 392.7 Equipment, inspection and use.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.7.md)
- [49 CFR § 392.8 § 392.8 Emergency equipment, inspection and use.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.8.md)
- [49 CFR § 392.9 § 392.9 Inspection of cargo, cargo securement devices and systems.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.9.md)
- [49 CFR § 392.9a § 392.9a Operating authority.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.9a.md)
- [49 CFR § 392.9b § 392.9b Prohibited transportation.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.9b.md)
- [49 CFR § 392.10 § 392.10 Railroad grade crossings; stopping required.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.10.md)
- [49 CFR § 392.11 § 392.11 Railroad grade crossings; slowing down required.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.11.md)
- [49 CFR § 392.12 § 392.12 Highway-rail crossings; safe clearance.](https://www.frixlaw.com/law-library/statutes/ecfr-49-392.12.md)

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Source: Frix Law Library, https://www.frixlaw.com/law-library/statutes/ecfr-49-392.4. Check the current official text before relying on it. Not legal advice.