# 21 CFR § 172.5: General provisions for direct food additives

> Federal · Regulations · In force

URL: https://www.frixlaw.com/law-library/statutes/ecfr-21-172.5

## Section

- **Citation:** 21 CFR § 172.5
- **Heading:** General provisions for direct food additives
- **Jurisdiction:** Federal
- **Kind:** Regulations
- **Status:** In force
- **Text as of:** September 22, 2026
- **Source:** Publisher's official text
- **Location:** Title 21—Food and Drugs > CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES > SUBCHAPTER B—FOOD FOR HUMAN CONSUMPTION > PART 172—FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION > Subpart A—General Provisions

## Text

(a) Regulations prescribing conditions under which food additive substances may be safely used predicate usage under conditions of good manufacturing practice. For the purposes of this part, good manufacturing practice shall be defined to include the following restrictions.
(1) The quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food.
(2) Any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.
(b) The existence of a regulation prescribing safe conditions of use for a food additive shall not be construed to relieve the use of the substance from compliance with any other provision of the Act.
(c) The existence of any regulation prescribing safe conditions of use for a nutrient substance does not constitute a finding that the substance is useful or required as a supplement to the diet of humans.

## Nearby sections

- [21 CFR § 172.5 § 172.5 General provisions for direct food additives.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.5.md)
- [21 CFR § 172.105 § 172.105 Anoxomer.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.105.md)
- [21 CFR § 172.110 § 172.110 BHA.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.110.md)
- [21 CFR § 172.115 § 172.115 BHT.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.115.md)
- [21 CFR § 172.120 § 172.120 Calcium disodium EDTA.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.120.md)
- [21 CFR § 172.130 § 172.130 Dehydroacetic acid.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.130.md)
- [21 CFR § 172.133 § 172.133 Dimethyl dicarbonate.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.133.md)
- [21 CFR § 172.135 § 172.135 Disodium EDTA.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.135.md)
- [21 CFR § 172.140 § 172.140 Ethoxyquin.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.140.md)
- [21 CFR § 172.145 § 172.145 Heptylparaben.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.145.md)
- [21 CFR § 172.150 § 172.150 4-Hydroxymethyl-2,6-di-tert-butylphenol.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.150.md)
- [21 CFR § 172.155 § 172.155 Natamycin (pimaricin).](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.155.md)
- [21 CFR § 172.160 § 172.160 Potassium nitrate.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.160.md)
- [21 CFR § 172.165 § 172.165 Quaternary ammonium chloride combination.](https://www.frixlaw.com/law-library/statutes/ecfr-21-172.165.md)

---

Source: Frix Law Library, https://www.frixlaw.com/law-library/statutes/ecfr-21-172.5. Check the current official text before relying on it. Not legal advice.