# 49 C.F.R. § 392.4 (2026): Drugs and other substances

> Federal · Regulations · In force

URL: https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_4

## Section

- **Citation:** 49 C.F.R. § 392.4 (2026)
- **Heading:** Drugs and other substances
- **Jurisdiction:** Federal
- **Kind:** Regulations
- **Status:** In force
- **Text as of:** August 14, 2026
- **Source:** Compiled text
- **Location:** Title 49 CFR: Transportation / Chapter III: FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION / Part 392: DRIVING OF COMMERCIAL MOTOR VEHICLES / Subpart A: General / § 392.4: § 392.4   Drugs and other substances.

## Text

(a) No driver shall be on duty and possess, be under the influence of, or use, any of the following drugs or other substances:
(1) Any 21 CFR 1308.11
Schedule I
substance;
(2) An amphetamine or any formulation thereof (including, but not limited, to “pep pills,” and “bennies”);
(3) A narcotic drug or any derivative thereof; or
(4) Any other substance, to a degree which renders the driver incapable of safely operating a motor vehicle.
(b) No motor carrier shall require or permit a driver to violate paragraph (a) of this section.
(c) Paragraphs (a) (2), (3), and (4) do not apply to the possession or use of a substance administered to a driver by or under the instructions of a licensed medical practitioner, as defined in § 382.107 of this subchapter, who has advised the driver that the substance will not affect the driver's ability to safely operate a motor vehicle.
(d) As used in this section, “possession” does not include possession of a substance which is manifested and transported as part of a shipment.
[61 FR 9567, Mar. 8, 1996, as amended at 62 FR 37153, July 11, 1997]

## Nearby sections

- [49 C.F.R. § 392.1 (2026) § 392.1   Scope of the rules in this part.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_1.md)
- [49 C.F.R. § 392.2 (2026) § 392.2   Applicable operating rules.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_2.md)
- [49 C.F.R. § 392.3 (2026) § 392.3   Ill or fatigued operator.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_3.md)
- [49 C.F.R. § 392.4 (2026) § 392.4   Drugs and other substances.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_4.md)
- [49 C.F.R. § 392.5 (2026) § 392.5   Alcohol prohibition.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_5.md)
- [49 C.F.R. § 392.6 (2026) § 392.6   Schedules to conform with speed limits.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_6.md)
- [49 C.F.R. § 392.7 (2026) § 392.7   Equipment, inspection and use.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_7.md)
- [49 C.F.R. § 392.8 (2026) § 392.8   Emergency equipment, inspection and use.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_8.md)
- [49 C.F.R. § 392.9 (2026) § 392.9   Inspection of cargo, cargo securement devices and systems.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_9.md)
- [49 C.F.R. § 392.9a (2026) § 392.9a   Operating authority.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_9a.md)
- [49 C.F.R. § 392.9b (2026) § 392.9b   Prohibited transportation.](https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_9b.md)

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Source: Frix Law Library, https://www.frixlaw.com/law-library/statutes/CFR_T49_P392_S392_4. Check the current official text before relying on it. Not legal advice.