# 21 C.F.R. § 173.320 (2026): Chemicals for controlling microorganisms in cane-sugar and beet-sugar mills

> Federal · Regulations · In force

URL: https://www.frixlaw.com/law-library/statutes/CFR_T21_P173_S173_320

## Section

- **Citation:** 21 C.F.R. § 173.320 (2026)
- **Heading:** Chemicals for controlling microorganisms in cane-sugar and beet-sugar mills
- **Jurisdiction:** Federal
- **Kind:** Regulations
- **Status:** In force
- **Text as of:** August 14, 2026
- **Source:** Compiled text
- **Location:** Title 21 CFR: Food and Drugs / Chapter I: FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES / Part 173: SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION / Subpart D: Specific Usage Additives / § 173.320: § 173.320   Chemicals for controlling microorganisms in cane-sugar and beet-sugar mills.

## Text

Agents for controlling microorganisms in cane-sugar and beet-sugar mills may be safely used in accordance with the following conditions:
(a) They are used in the control of microorganisms in cane-sugar and/or beet-sugar mills as specified in paragraph (b) of this section.
(b) They are applied to the sugar mill grinding, crusher, and/or diffuser systems in one of the combinations listed in paragraph (b)(1), (2), (3), or (5) of this section or as a single agent listed in paragraph (b)(4) or (6) of this section. Quantities of the individual additives in parts per million are expressed in terms of the weight of the raw cane or raw beets.
(1) Combination for cane-sugar mills:
Parts per million
Disodium cyanodithioimidocarbonate
2.5
Ethylenediamine
1.0
Potassium
N-
methyldithiocarbamate
3.5
(2) Combination for cane-sugar mills:
Parts per million
Disodium ethylenebisdithiocarbamate
3.0
Sodium dimethyldithiocarbamate
3.0
(3) Combinations for cane-sugar mills and beet-sugar mills:
Parts per million
(i) Disodium ethylenebisdithiocarbamate
3.0
Ethylenediamine
2.0
Sodium dimethyldithiocarbamate
3.0
(ii) Disodium cyanodithioimidocarbonate
2.9
Potassium
N-
methyldithiocarbamate
4.1
(4) Single additive for cane-sugar mills and beet-sugar mills.
Parts per million
2,2-Dibromo-3-nitrilopropionamide (CAS Reg. No. 10222-01-2).
Limitations:
Byproduct molasses, bagasse, and pulp containing residues of 2,2-dibromo-3-nitrilopropionamide are not authorized for use in animal feed
Not more than 10.0 and not less than 2.0.
anodithioimidocarbonate
2.9
Potassium
N-
methyldithiocarbamate
4.1
(4) Single additive for cane-sugar mills and beet-sugar mills.
Parts per million
2,2-Dibromo-3-nitrilopropionamide (CAS Reg. No. 10222-01-2).
Limitations:
Byproduct molasses, bagasse, and pulp containing residues of 2,2-dibromo-3-nitrilopropionamide are not authorized for use in animal feed
Not more than 10.0 and not less than 2.0.
(5) Combination for cane-sugar mills:
Parts per million
n-
Dodecyl dimethyl benzyl ammonium chloride
0.05±0.005
n-
Dodecyl dimethyl ethylbenzyl ammonium chloride
0.68±0.068
n-
Hexadecyl dimethyl benzyl ammonium chloride
0.30±0.030
n-
Octadecyl dimethyl benzyl ammonium chloride
0.05±0.005
n-
Tetradecyl dimethyl benzyl ammonium chloride
0.60±0.060
n-
Tetradecyl dimethyl ethylbenzyl ammonium chloride
0.32±0.032
Limitations.
Byproduct molasses, bagasse, and pulp containing residues of these quaternary ammonium salts are not authorized for use in animal feed.
(6) Single additive for beet-sugar mills:
Parts per million
Glutaraldehyde (CAS Reg. No. 111-30-8)
Not more than 250.
(c) To assure safe use of the additives, their label and labeling shall conform to that registered with the Environmental Protection Agency.
[42 FR 14526, Mar. 15, 1977, as amended at 47 FR 35756, Aug. 17, 1982; 50 FR 3891, Jan. 29, 1985; 57 FR 8065, Mar. 6, 1992]

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Source: Frix Law Library, https://www.frixlaw.com/law-library/statutes/CFR_T21_P173_S173_320. Check the current official text before relying on it. Not legal advice.