# Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

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URL: https://www.frixlaw.com/law-library/documents/fr%3AE8-28551

## Record

- **Collection:** Federal Register
- **Document type:** Notice
- **Published:** December 2, 2008
- **Citation:** 73 FR 73329

## Text

DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-248]
Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

AGENCY:

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

ACTION:

Request for comments on the proposed substances to be evaluated for Set 23 toxicological profiles.

SUMMARY:

This notice announces the list of proposed substances that will be evaluated for CERCLA Set 23 toxicological profile development. ATSDR's Division of Toxicology and Environmental Medicine is soliciting public nominations from the list of proposed substances to be evaluated for toxicological profile development. ATSDR also will consider the evaluation of any additional substances that may have public health implications.

DATES:

Nominations must be submitted by December 24th, 2008.

ADDRESSES:

Nominations may be submitted electronically, by mail, or by facsimile. Refer to the section
Submission of Nominations
(below) for specific addresses and/or the facsimile number.

FOR FURTHER INFORMATION:

Contact Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta, Georgia 30333, telephone (770) 488-3313.

SUPPLEMENTARY INFORMATION:

The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 U.S.C. 9601
et seq.
] amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 U.S.C. 9601
et seq.
] by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances. This list has identified 275 hazardous substances that ATSDR and EPA determined pose the most significant potential threat to human health. The availability of the revised list of the 275 priority substances was announced in the
Federal Register
on March 6, 2008 (73 FR 12178). For previous versions of the list of substances, see
Federal Register
notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 2005 (70 FR 70284).

Proposed Substances To Be Evaluated for Set 23 Toxicological Profiles

Each year, ATSDR develops a list of priority substances that will be evaluated for toxicological profile development. This list was compiled, on the basis of ATSDR's Priority List of Hazardous Substances, with consideration of the amount of relevance of newly published scientific

literature. The following 80 substances will be evaluated:

Name
CAS

1
MERCURY
007439-97-6

METHYLMERCURY
022967-92-6

MERCURIC CHLORIDE
007487-94-7

2
POLYCHLORINATED BIPHENYLS
001336-36-3

AROCLOR 1254
011097-69-1

AROCLOR 1260
011096-82-5

AROCLOR 1248
012672-29-6

AROCLOR 1242
053469-21-9

AROCLOR
012767-79-2

AROCLOR 1221
011104-28-2

AROCLOR 1016
012674-11-2

AROCLOR 1232
011141-16-5

AROCLOR 1240
071328-89-7

TETRACHLOROBIPHENYL
026914-33-0

3
POLYCYCLIC AROMATIC HYDROCARBONS
130498-29-2

BENZO(A)PYRENE
000050-32-8

BENZO(B)FLUORANTHENE
000205-99-2

DIBENZO(A,H)ANTHRACENE
000053-70-3

BENZO(A)ANTHRACENE
000056-55-3

BENZO(K)FLUORANTHENE
000207-08-9

BENZOFLUORANTHENE
056832-73-6

FLUORANTHENE
000206-44-0

CHRYSENE
000218-01-9

ACENAPHTHENE
000083-32-9

INDENO(1,2,3-CD)PYRENE
000193-39-5

BENZOPYRENE
073467-76-2

PHENANTHRENE
000085-01-8

PYRENE
000129-00-0

FLUORENE
000086-73-7

ANTHRACENE
000120-12-7

BENZO(A)FLUORANTHENE
000203-33-8

BENZO(GHI)PERYLENE
000191-24-2

ACENAPHTHYLENE
000208-96-8

BENZO(J)FLUORANTHENE
000205-82-3

BENZO(E)PYRENE
000192-97-2

BENZOPERYLENE
011057-45-7

BENZO(B)ANTHRACENE
000092-24-0

DIBENZ(A,J)ANTHRACENE
000224-41-9

BENZO(GHI)FLUORANTHENE
000203-12-3

1-METHYLPYRENE
002381-21-7

4
CHLOROFORM
000067-66-3

5
DDT, P,P′-
000050-29-3

DDE, P,P′-
000072-55-9

DDD, P,P′-
000072-54-8

DDT, O,P′-
000789-02-6

DDD, O,P′
-000053-19-0

DDE, O,P′-
003424-82-6

6
TRICHLOROETHYLENE
000079-01-6

7
DIELDRIN
000060-57-1

ALDRIN
000309-00-2

8
CHLORDANE
000057-74-9

CIS-CHLORDANE
005103-71-9

TRANS-CHLORDANE
005103-74-2

OXYCHLORDANE
027304-13-8

GAMMA-CHLORDENE
056641-38-4

CHLORDANE, TECHNICAL
012789-03-6

ALPHA-CHLORDENE
056534-02-2

NONACHLOR, TRANS-
039765-80-5

NONACHLOR, CIS-
005103-73-1

CHLORDENE
003734-48-3

9
HEXACHLOROBUTADIENE
000087-68-3

10
COAL TAR CREOSOTE
008001-58-9

COAL TARS
008007-45-2

COAL TAR PITCH
065996-93-2

11
BENZIDINE
000092-87-5

12
TOXAPHENE
008001-35-2

13
TETRACHLOROETHYLENE
000127-18-4

14
1,2-DIBROMOETHANE
000106-93-4

15
DISULFOTON
000298-04-4

16
3,3′-DICHLOROBENZIDINE
000091-94-1

17
ENDRIN
000072-20-8

ENDRIN KETONE
053494-70-5

ENDRIN ALDEHYDE
007421-93-4

18
BERYLLIUM
007440-41-7

19
1,2-DIBROMO-3-CHLOROPROPANE
000096-12-8

DIBROMOCHLOROPROPANE
067708-83-2

20
PENTACHLOROPHENOL
000087-86-5

21
DI-N-BUTYL PHTHALATE
000084-74-2

22
ENDOSULFAN
000115-29-7

ENDOSULFAN SULFATE
001031-07-8

ENDOSULFAN, ALPHA
000959-98-8

ENDOSULFAN, BETA
033213-65-9

23
METHOXYCHLOR
000072-43-5

24
METHANE
000074-82-8

25
TOLUENE
000108-88-3

26
2-HEXANONE
000591-78-6

27
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN
001746-01-6

HEXACHLORODIBENZO-P-DIOXIN
034465-46-8

HEPTACHLORODIBENZO-P-DIOXIN
037871-00-4

TETRACHLORODIBENZO-P-DIOXIN
041903-57-5

PENTACHLORODIBENZO-P-DIOXIN
036088-22-9

1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN
035822-46-9

OCTACHLORODIBENZO-P-DIOXIN
003268-87-9

1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN
057653-85-7

1,2,3,4,7,8-HEXACHLORODIBENZO-P-DIOXIN
039227-28-6

1,2,3,7,8,9-HEXACHLORODIBENZO-P-DIOXIN
019408-74-3

1,2,3,7,8-PENTACHLORODIBENZO-P-DIOXIN
040321-76-4

28
DI(2-ETHYLHEXYL)PHTHALATE
000117-81-7

29
1,1-DICHLOROETHENE
000075-35-4

30
METHYLENE CHLORIDE
000075-09-2

31
BROMODICHLOROETHANE
000683-53-4

32
1,2-DICHLOROETHANE
000107-06-2

33
2,4,6-TRICHLOROPHENOL
000088-06-2

TETRACHLOROPHENOL
025167-83-3

2,4-DICHLOROPHENOL
000120-83-2

2,4,5-TRICHLOROPHENOL
000095-95-4

2-CHLOROPHENOL
000095-57-8

2,3,4,5-TETRACHLOROPHENOL
004901-51-3

2,3,5,6-TETRACHLOROPHENOL
000935-95-5

2,3,4,6-TETRACHLOROPHENOL
000058-90-2

4-CHLOROPHENOL
000106-48-9

CHLOROPHENOL
025167-80-0

34
2,4-DINITROPHENOL
000051-28-5

35
BIS(2-CHLOROETHYL) ETHER
000111-44-4

36
ASBESTOS
001332-21-4

CHRYSOTILE ASBESTOS
012001-29-5

AMOSITE ASBESTOS
012172-73-5

37
HEXACHLOROBENZENE
000118-74-1

38
2,4-DINITROTOLUENE
000121-14-2

DINITROTOLUENE
025321-14-6

2,6-DINITROTOLUENE
000606-20-2

39
RADIUM-226
013982-63-3

RADIUM
007440-14-4

RADIUM-228
015262-20-1

RADIUM-224
013233-32-4

40
ETHION
000563-12-2

41
THORIUM
007440-29-1

THORIUM-230
014269-63-7

THORIUM-228
014274-82-9

42
4,6-DINITRO-O-CRESOL
000534-52-1

42
CHLOROBENZENE
000108-90-7

44
N-NITROSODI-N-PROPYLAMINE
000621-64-7

45
1,2,3-TRICHLOROBENZENE
000087-61-6

46
POLONIUM-210
013981-52-7

47
CHLORPYRIFOS
002921-88-2

48
NEPTUNIUM-237
013994-20-2

49
CHLORDECONE
000143-50-0

MIREX
002385-85-5

50
S,S,S-TRIBUTYL PHOSPHOROTRITHIOATE
000078-48-8

51
BROMINE
007726-95-6

52
DICOFOL
000115-32-2

53
PARATHION
000056-38-2

54
SELENIUM
007782-49-2

55
TRICHLOROFLUOROETHANE
027154-33-2

56
TRIFLURALIN
001582-09-8

57
4,4′-METHYLENEBIS(2-CHLOROANILINE)
000101-14-4

58
PENTACHLOROBENZENE
000608-93-5

59
1,3-BUTADIENE
000106-99-0

60
1,1-DICHLOROETHANE
000075-34-3

61
1,2,3,4,6,7,8,9-OCTACHLORODIBENZOFURAN
039001-02-0

HEPTACHLORODIBENZOFURAN
038998-75-3

2,3,4,7,8-PENTACHLORODIBENZOFURAN
057117-31-4

HEXACHLORODIBENZOFURAN
055684-94-1

PENTACHLORODIBENZOFURAN
030402-15-4

2,3,7,8-TETRACHLORODIBENZOFURAN
051207-31-9

DIBENZOFURANS, CHLORINATED
042934-53-2

1,2,3,4,6,7,8-HEPTACHLORODIBENZOFURAN
067562-39-4

1,2,3,7,8,9-HEXACHLORODIBENZOFURAN
072918-21-9

TETRACHLORODIBENZOFURAN
030402-14-3

1,2,3,6,7,8-HEXACHLORODIBENZOFURAN
057117-44-9

1,2,3,4,7,8-HEXACHLORODIBENZOFURAN
070648-26-9

2,3,4,6,7,8-HEXACHLORODIBENZOFURAN
060851-34-5

1,2,3,7,8-PENTACHLORODIBENZOFURAN
057117-41-6

1,2,3,4,7,8,9-HEPTACHLORODIBENZOFURAN
055673-89-7

62
1,1,2-TRICHLOROETHANE
000079-00-5

63
HEXACHLOROCYCLOPENTADIENE
000077-47-4

64
1,2-DIPHENYLHYDRAZINE
000122-66-7

65
1,2-DICHLOROETHENE, TRANS-
000156-60-5

1,2-DICHLOROETHYLENE
000540-59-0

1,2-DICHLOROETHENE, CIS-
000156-59-2

66
CARBON DISULFIDE
000075-15-0

67
PALLADIUM
007440-05-3

68
CHLOROETHANE
000075-00-3

98
ACETONE
000067-64-1

70
DIBENZOFURAN
000132-64-9

71
2,4-DIMETHYLPHENOL
000105-67-9

72
CARBON MONOXIDE
000630-08-0

73
CHLOROMETHANE
000074-87-3

74
BUTYL BENZYL PHTHALATE
000085-68-7

75
VANADIUM
007440-62-2

76
N-NITROSODIMETHYLAMINE
000062-75-9

77
1,2,4-TRICHLOROBENZENE
000120-82-1

78
N-NITROSODIPHENYLAMINE
000086-30-6

79
2-BUTANONE
000078-93-3

80
FLUORINE
007782-41-4

HYDROGEN FLUORIDE
007664-39-3

FLUORIDE ION
016984-48-8

Submission of Nominations for the Evaluation Set 23 Proposed Substances:
Today's notice also invites voluntary public nominations for substances not listed in this notice. Nominations are most useful if they include the full name, title, affiliation, e-mail address and telephone number of the nominator.

ATSDR will evaluate all data and information associated with nominated substances and will determine the final list of substances that will be chosen for toxicological profile development. Substances will be chosen according to ATSDR's specific guidelines for selection, found in the
Selection Criteria
announced in the
Federal Register
on May 7th, 1993 (87 FR 27288).

Please submit nominations by one of the following methods:

• E-mail
jxt1@cdc.gov
.

• Fax 770.488.4178.

• Mail CDR Jessilynn Taylor, 1600 Clifton Rd, NE., MS F32, Atlanta, GA 30333.

Please ensure that your comments are submitted within the specified nomination period. Nominations received after the closing date will be marked as late and may be considered only if time permits.

Dated: November 26, 2008.
Ken Rose,
Director, Office of Policy, Planning, and Evaluation National Center for Environmental Health/Agency for Toxic Substances and Disease Registry.

[FR Doc. E8-28551 Filed 12-1-08; 8:45 am]
BILLING CODE 4163-70-P

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Source: Frix Law Library, https://www.frixlaw.com/law-library/documents/fr%3AE8-28551. Public record. Not legal advice.