# Proposed Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2019 > Briefs, arguments, decisions, and more. URL: https://www.frixlaw.com/law-library/documents/fr%3A2018-17893 ## Record - **Collection:** Federal Register - **Document type:** Notice - **Published:** August 20, 2018 - **Citation:** 83 FR 42164 ## Text DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. DEA-488P] Proposed Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2019 AGENCY: Drug Enforcement Administration, Department of Justice. ACTION: Notice with request for comments. SUMMARY: The Drug Enforcement Administration (DEA) proposes to establish the 2019 aggregate production quotas for controlled substances in schedules I and II of the Controlled Substances Act and assessment of annual needs for the list I chemicals ephedrine, pseudoephedrine, and phenylpropanolamine. DATES: Interested persons may file written comments on this notice in accordance with 21 CFR 1303.11(c) and 1315.11(d). Electronic comments must be submitted, and written comments must be postmarked, on or before September 19, 2018. Commenters should be aware that the electronic Federal Docket Management System will not accept comments after 11:59 p.m. Eastern Time on the last day of the comment period. Based on comments received in response to this notice, the Administrator may hold a public hearing on one or more issues raised. In the event the Administrator decides in his sole discretion to hold such a hearing, the Administrator will publish a notice of any such hearing in the Federal Register . After consideration of any comments or objections, or after a hearing, if one is held, the Administrator will publish in the Federal Register a final order establishing the 2019 aggregate production quotas for schedule I and II controlled substances, and an assessment of annual needs for the list I chemicals ephedrine, pseudoephedrine, and phenylpropanolamine. ADDRESSES: To ensure proper handling of comments, please reference “Docket No. DEA-488P” on all correspondence, including any attachments. The Drug Enforcement Administration encourages that all comments be submitted electronically through the Federal eRulemaking Portal, which provides the ability to type short comments directly into the comment field on the web page or attach a file for lengthier comments. Please go to http://www.regulations.gov and follow the online instructions at that site for submitting comments. Upon completion of your submission you will receive a Comment Tracking Number for your comment. Please be aware that submitted comments are not instantaneously available for public view on regulations.gov. If you have received a Comment Tracking Number, your comment has been successfully submitted and there is no need to resubmit the same comment. Paper comments that duplicate electronic submissions are not necessary and are discouraged. Should you wish to mail a paper comment in lieu of an electronic comment, it should be sent via regular or express mail to: Drug Enforcement Administration, Attention: DEA Federal Register Representative/DRW, 8701 Morrissette Drive, Springfield, Virginia 22152. FOR FURTHER INFORMATION CONTACT: Thomas D. Sonnen, Diversion Control Division, Drug Enforcement Administration; Mailing Address: 8701 Morrissette Drive, Springfield, Virginia 22152, Telephone: (202) 598-6812. SUPPLEMENTARY INFORMATION: Posting of Public Comments Please note that all comments received in response to this docket are considered part of the public record. They will, unless reasonable cause is given, be made available by the Drug Enforcement Administration (DEA) for public inspection online at http://www.regulations.gov. Such information includes personal identifying information (such as your name, address, etc.) voluntarily submitted by the commenter. The Freedom of Information Act (FOIA) applies to all comments received. If you want to submit personal identifying information (such as your name, address, etc.) as part of your comment, but do not want it to be made publicly available, you must include the phrase “PERSONAL IDENTIFYING INFORMATION” in the first paragraph of your comment. You must also place all the personal identifying information you do not want made publicly available in the first paragraph of your comment and identify what information you want redacted. If you want to submit confidential business information as part of your comment, but do not want it to be made publicly available, you must include the phrase “CONFIDENTIAL BUSINESS INFORMATION” in the first paragraph of your comment. You must also prominently identify confidential business information to be redacted within the comment. Comments containing personal identifying information or confidential business information identified and located as directed above will generally be made available in redacted form. If a comment contains so much confidential business information or personal identifying information that it cannot be effectively redacted, all or part of that comment may not be made publicly available. Comments posted to http://www.regulations.gov may include any personal identifying information (such as name, address, and phone number) included in the text of your electronic submission that is not identified as directed above as confidential. An electronic copy of this document is available at http://www.regulations.gov for easy reference. Legal Authority Section 306 of the Controlled Substances Act (CSA) (21 U.S.C. 826) requires the Attorney General to establish aggregate production quotas for each basic class of controlled substance listed in schedules I and II and for the list I chemicals ephedrine, pseudoephedrine, and phenylpropanolamine. The Attorney General has delegated this function to the Administrator of the DEA pursuant to 28 CFR 0.100. Analysis for Proposed 2019 Aggregate Production Quotas and Assessment of Annual Needs The proposed year 2019 aggregate production quotas and assessment of annual needs represent those quantities of schedule I and II controlled substances, and the list I chemicals ephedrine, pseudoephedrine, and phenylpropanolamine, to be manufactured in the United States in 2019 to provide for the estimated medical, scientific, research, and industrial needs of the United States, lawful export requirements, and the establishment and maintenance of reserve stocks. These quotas include imports of ephedrine, pseudoephedrine, and phenylpropanolamine, but do not include imports of controlled substances for use in industrial processes. In determining the proposed 2019 aggregate production quotas and assessment of annual needs, the Acting Administrator has taken into account the criteria in 21 U.S.C. 826(a) and factors set forth in 21 CFR 1303.11 (aggregate production quotas for controlled substances) and 21 CFR 1315.11 (assessment of annual needs for ephedrine, pseudoephedrine, and phenylpropanolamine). The DEA proposes the aggregate production quotas and assessment of annual needs for 2019 by considering: (1) Total net disposal of each class or chemical by all manufacturers and chemical importers during the current and two preceding years; (2) trends in the national rate of net disposal of the class or chemical; (3) total actual (or estimated) inventories of the class or chemical and of all substances manufactured from the class or chemical, and trends in inventory accumulation; (4) projected demand for each class or chemical as indicated by procurement and import quotas requested in accordance with 21 CFR 1303.12, 1315.32, and 1315.34; and (5) other factors affecting medical, scientific, research, and industrial needs of the United States and lawful export requirements, as the Acting Administrator finds relevant. These quotas do not include imports of controlled substances for use in industrial processes. Other factors the Acting Administrator considered in calculating the aggregate production quotas, but not the assessment of annual needs, include product development requirements of both bulk and finished dosage form manufacturers, and other pertinent information. In determining the proposed 2019 assessment of annual needs, the DEA used the calculation methodology previously described in the 2010 and 2011 assessment of annual needs (74 FR 60294, Nov. 20, 2009, and 75 FR 79407, Dec. 20, 2010, respectively). On July 16, 2018, DEA published a final rule regarding controlled substances quotas with an effective date of August 15, 2018 (“Controlled Substances Quotas Final Rule”). 83 FR 32784. The Controlled Substances Quotas Final Rule added two factors for DEA to consider when setting aggregate production quotas and assessments of annual needs. These additional factors are: (1) The extent of any diversion of the controlled substance in the class; and (2) relevant information obtained from the Department of Health and Human Services, including from the Food and Drug Administration, the Centers for Disease Control and Prevention, and the Centers for Medicare and Medicaid Services, and relevant information obtained from the states. The proposed aggregate quotas for 2019 in this notice were determined with consideration of the factors in effect prior to the effective date of the Controlled Substances Quotas Final Rule. The Acting Administrator, therefore, proposes to establish the 2019 aggregate production quotas for certain schedule I and II controlled substances and assessment of annual needs for the list I chemicals ephedrine, pseudoephedrine, and phenylpropanolamine, expressed in grams of anhydrous acid or base, as follows: Basic class Proposed 2019 quotas (g) Schedule I 1-[1-(2-Thienyl)cyclohexyl]pyrrolidine 20 1-(1-Phenylcyclohexyl)pyrrolidine 15 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine 10 1-(5-Fluoropentyl)-3-(1-naphthoyl)indole (AM2201) 30 1-(5-Fluoropentyl)-3-(2-iodobenzoyl)indole (AM694) 30 1-Benzylpiperazine 25 1-Methyl-4-phenyl-4-propionoxypiperidine 10 1-[1-(2-Thienyl)cyclohexyl]piperidine 15 2-(2,5-Dimethoxy-4-ethylphenyl)ethanamine (2C-E) 30 2-(2,5-Dimethoxy-4-methylphenyl)ethanamine (2C-D) 30 2-(2,5-Dimethoxy-4-nitro-phenyl)ethanamine (2C-N) 30 2-(2,5-Dimethoxy-4-n-propylphenyl)ethanamine (2C-P) 30 2-(2,5-Dimethoxyphenyl)ethanamine (2C-H) 30 2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe; 2C-B-NBOMe; 25B; Cimbi-36) 30 2-(4-Chloro-2,5-dimethoxyphenyl)ethanamine (2C-C) 30 2-(4-Chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82) 25 2-(4-Iodo-2,5-dimethoxyphenyl)ethanamine (2C-I) 30 2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5) 30 2,5-Dimethoxy-4-ethylamphetamine (DOET) 25 2,5-Dimethoxy-4-n-propylthiophenethylamine 25 2,5-Dimethoxyamphetamine 25 2-[4-(Ethylthio)-2,5-dimethoxyphenyl]ethanamine (2C-T-2) 30 2-[4-(Isopropylthio)-2,5-dimethoxyphenyl]ethanamine (2C-T-4) 30 3,4,5-Trimethoxyamphetamine 30 3,4-Methylenedioxyamphetamine (MDA) 55 3,4-Methylenedioxymethamphetamine (MDMA) 50 3,4-Methylenedioxy-N-ethylamphetamine (MDEA) 40 3,4-Methylenedioxy-N-methylcathinone (methylone) 40 3,4-Methylenedioxypyrovalerone (MDPV) 35 3-FMC; 3-Fluoro-N-methylcathinone 25 3-Methylfentanyl 30 3-Methylthiofentanyl 30 4-Bromo-2,5-dimethoxyamphetamine (DOB) 30 4-Bromo-2,5-dimethoxyphenethylamine (2-CB) 25 1-(4-Cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboximide 25 4-Fluoroisobutyryl fentanyl 30 4-FMC; Flephedrone 25 4-MEC; 4-Methyl-N-ethylcathinone 25 4-Methoxyamphetamine 150 4-Methyl-2,5-dimethoxyamphetamine (DOM) 25 4-Methylaminorex 25 4-Methyl-N-methylcathinone (mephedrone) 45 4-Methyl-α-pyrrolidinopropiophenone (4-MePPP) 25 5-(1,1-Dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-phenol 50 5-(1,1-Dimethyloctyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-phenol (cannabicyclohexanol or CP-47,497 C8-homolog) 40 N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide 25 1-(5-Fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3carboximide 25 5F-ADB; 5F-MDMB-PINACA (methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate) 30 5F-AMB (methyl 2-(1-(5-fluoropentyl)-1 H -indazole-3-carboxamido)-3-methylbutanoate) 30 5F-APINACA; 5F-AKB48 ( N -(adamantan-1-yl)-1-(5-fluoropentyl)-1 H -indazole-3-carboxamide) 30 5-Fluoro-PB-22; 5F-PB-22 20 5-Fluoro-UR144, XLR11 ([1-(5-fluoro-pentyl)-1 H indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone 25 5-Methoxy-3,4-methylenedioxyamphetamine 25 5-Methoxy-N,N-diisopropyltryptamine 25 5-Methoxy-N,N-dimethyltryptamine 25 AB-CHMINACA 30 AB-FUBINACA 50 AB-PINACA 30 ADB-FUBINACA ( N -(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1 H -indazole-3-carboxamide) 30 Acetyl Fentanyl 100 Acetyl- alpha -methylfentanyl 30 Acetyldihydrocodeine 30 Acetylmethadol 2 Acryl Fentanyl 25 ADB-PINACA ( N -(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1 H -indazole-3-carboxamide) 50 AH-7921 30 Allylprodine 2 Alphacetylmethadol 2 alpha- Ethyltryptamine 25 Alphameprodine 2 Alphamethadol 2 alpha -Methylfentanyl 30 alpha -Methylthiofentanyl 30 alpha -Methyltryptamine (AMT) 25 alpha -Pyrrolidinobutiophenone (α-PBP) 25 alpha -Pyrrolidinopentiophenone (α-PVP) 25 Aminorex 25 Anileridine 20 APINCA, AKB48 ( N -(1-adamantyl)-1-pentyl-1 H -indazole-3-carboxamide) 25 Benzylmorphine 30 Betacetylmethadol 2 beta -Hydroxy-3-methylfentanyl 30 beta -Hydroxyfentanyl 30 beta -Hydroxythiofentanyl 30 Betameprodine 2 Betamethadol 4 Betaprodine 2 Bufotenine 3 Butylone 25 Butyryl fentanyl 30 Cathinone 24 Codeine methylbromide 30 Codeine-N-oxide 192 Cyclopropyl Fentanyl 20 Desomorphine 25 Diapromide 20 Diethylthiambutene 20 Diethyltryptamine 25 Difenoxin 8,225 Dihydromorphine 753,500 Dimethyltryptamine 50 Dipipanone 5 Etorphine 30 Fenethylline 30 Fentanyl related substances 25 Furanyl fentanyl 30 gamma -Hydroxybutyric acid 33,417,000 Heroin 45 Hydromorphinol 40 Hydroxypethidine 2 Ibogaine 30 Isobutyryl Fentanyl 25 JWH-018 and AM678 (1-Pentyl-3-(1-naphthoyl)indole) 35 JWH-019 (1-Hexyl-3-(1-naphthoyl)indole) 45 JWH-073 (1-Butyl-3-(1-naphthoyl)indole) 45 JWH-081 (1-Pentyl-3-[1-(4-methoxynaphthoyl)]indole) 30 JWH-122 (1-Pentyl-3-(4-methyl-1-naphthoyl)indole) 30 JWH-200 (1-[2-(4-Morpholinyl)ethyl]-3-(1-naphthoyl)indole) 35 JWH-203 (1-Pentyl-3-(2-chlorophenylacetyl)indole) 30 JWH-250 (1-Pentyl-3-(2-methoxyphenylacetyl)indole) 30 JWH-398 (1-Pentyl-3-(4-chloro-1-naphthoyl)indole) 30 Lysergic acid diethylamide (LSD) 40 MAB-CHMINACA; ADB-CHMINACA ( N -(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1 H -indazole-3-carboxamide) 30 MDMB-CHMICA; MMB-CHMINACA(methyl 2-(1-(cyclohexylmethyl)-1 H -indole-3-carboxamido)-3,3-dimethylbutanoate) 30 MDMB-FUBINACA (methyl 2-(1-(4-fluorobenzyl)-1 H -indazole-3-carboxamido)-3,3-dimethylbutanoate) 30 Methyl-2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3-methylbutanoate 25 Marihuana 2,450,000 Mecloqualone 30 Mescaline 25 Methaqualone 60 Methcathinone 25 Methyldesorphine 5 Methyldihydromorphine 2 Morphine methylbromide 5 Morphine methylsulfonate 5 Morphine-N-oxide 150 Naphthalen-1-yl 1-(5-fluorpentyl)-1H-indole-3-carboxylate 25 N,N -Dimethylamphetamine 25 Naphyrone 25 N -Ethyl-1-phenylcyclohexylamine 5 N -Ethyl-3-piperidyl benzilate 10 N -Ethylamphetamine 24 N -Hydroxy-3,4-methylenedioxyamphetamine 24 Noracymethadol 2 Norlevorphanol 55 Normethadone 2 Normorphine 40 Ocfentanil 25 Para-fluorofentanyl 25 Para-flourobutyryl fentanyl 25 Parahexyl 5 PB-22; QUPIC 20 Pentedrone 25 Pentylone 25 Phenomorphan 2 Pholcodine 5 Psilocybin 30 Psilocyn 50 SR-18 and RCS-8 (1-Cyclohexylethyl-3-(2-methoxyphenylacetyl)indole) 45 SR-19 and RCS-4 (1-Pentyl-3-[(4-methoxy)-benzoyl]indole) 30 Tetrahydrocannabinols 384,460 Tetrahydrofuranyl fentanyl 5 Thiofentanyl 25 THJ-2201 ( [1-(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone) 30 Tilidine 25 Trimeperidine 2 UR-144 (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone 25 U-47700 30 Valeryl fentanyl 25 Schedule II 1-Phenylcyclohexylamine 15 1-Piperidinocyclohexanecarbonitrile 25 4-Anilino-N-phenethyl-4-piperidine (ANPP) 1,185,000 Alfentanil 6,200 Alphaprodine 2 Amobarbital 20,100 Amphetamine (for conversion) 12,000,000 Amphetamine (for sale) 42,400,000 Carfentanil 20 Cocaine 92,120 Codeine (for conversion) 13,536,000 Codeine (for sale) 40,015,800 Dextropropoxyphene 35 Dihydrocodeine 238,466 Dihydroetorphine 2 Diphenoxylate (for conversion) 14,100 Diphenoxylate (for sale) 770,800 Ecgonine 88,134 Ethylmorphine 30 Etorphine hydrochloride 32 Fentanyl 1,185,000 Glutethimide 2 Hydrocodone (for conversion) 5,000 Hydrocodone (for sale) 44,710,000 Hydromorphone 4,071,000 Isomethadone 30 Levo-alphacetylmethadol (LAAM) 5 Levomethorphan 4,000 Levorphanol 34,000 Lisdexamfetamine 19,000,000 Meperidine 1,580,000 Meperidine Intermediate-A 30 Meperidine Intermediate-B 30 Meperidine Intermediate-C 30 Metazocine 15 Methadone (for sale) 22,278,000 Methadone Intermediate 24,064,000 Methamphetamine 1,446,754 [846,000 grams of levo-desoxyephedrine for use in a non-controlled, non-prescription product; 564,000 grams for methamphetamine mostly for conversion to a schedule III product; and 36,754 grams for methamphetamine (for sale)] Methylphenidate 64,600,000 Morphine (for conversion) 4,089,000 Morphine (for sale) 31,456,000 Nabilone 62,000 Noroxymorphone (for conversion) 19,169,340 Noroxymorphone (for sale) 376,000 Opium (powder) 84,600 Opium (tincture) 530,837 Oripavine 28,705,000 Oxycodone (for conversion) 2,081,000 Oxycodone (for sale) 85,578,000 Oxymorphone (for conversion) 24,525,540 Oxymorphone (for sale) 2,880,000 Pentobarbital 25,850,000 Phenazocine 5 Phencyclidine 35 Phenmetrazine 25 Phenylacetone 40 Racemethorphan 5 Racemorphan 5 Remifentanil 3,000 Secobarbital 172,100 Sufentanil 1,880 Tapentadol 18,388,280 Thebaine 84,600,000 List I Chemicals Ephedrine (for conversion) 25 Ephedrine (for sale) 4,136,000 Phenylpropanolamine (for conversion) 14,100,000 Phenylpropanolamine (for sale) 7,990,000 Pseudoephedrine (for conversion) 1,000 Pseudoephedrine (for sale) 174,246,000 The Acting Administrator further proposes that aggregate production quotas for all other schedule I and II controlled substances included in 21 CFR 1308.11 and 1308.12 remain at zero. In accordance with 21 CFR 1303.13 and 21 CFR 1315.13, upon consideration of the relevant factors, the Acting Administrator may adjust the 2019 aggregate production quotas and assessment of annual needs as needed. Conclusion After consideration of any comments or objections, or after a hearing, if one is held, the Acting Administrator will issue and publish in the Federal Register a final order establishing the 2019 aggregate production quotas for controlled substances in schedules I and II and establishing an assessment of annual needs for the list I chemicals ephedrine, pseudoephedrine, and phenylpropanolamine, 21 CFR 1303.11(c) and 1315.11(f). Dated: August 14, 2018. Uttam Dhillon, Acting Administrator. [FR Doc. 2018-17893 Filed 8-17-18; 8:45 am] BILLING CODE 4410-09-P --- Source: Frix Law Library, https://www.frixlaw.com/law-library/documents/fr%3A2018-17893. Public record. Not legal advice.